Sub-20 nm LiErF4-Based Upconversion Nanophosphors for Simultaneous Imaging and Photothermal Therapeutics
- Authors
- Hong, A-Ra; Byun, Ji Young; Lee, Kwangyeol; Jang, Ho Seong
- Issue Date
- 25-9월-2020
- Publisher
- AMER CHEMICAL SOC
- Keywords
- red upconversion; LiErF4; core/triple-shell; ultrasmall nanophosphors; photothermal property
- Citation
- ACS APPLIED NANO MATERIALS, v.3, no.9, pp.8662 - 8671
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED NANO MATERIALS
- Volume
- 3
- Number
- 9
- Start Page
- 8662
- End Page
- 8671
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/53108
- DOI
- 10.1021/acsanm.0c01383
- ISSN
- 2574-0970
- Abstract
- This study reports red-emitting LiErF4:Tm-based upconversion nanophosphors (UCNPs) with small size and high brightness for simultaneous upconversion luminescence (UCL) imaging and photothermal therapeutics. Strong red UCL is realized from LiErF4-based UCNPs by doping Tm3+ into LiErF4 and forming multishells on the LiErF4:Tm core. The ultrasmall LiErF4:Tm UCNPs are facilely synthesized by using rare-earth-oleate precursors and a mixed solvent of oleic acid and 1-octadecene. The size of the ultrasmall LiErF4:Tm(0.3%) UCNPs is finely tuned from 2.8 to 10.4 nm, and LiErF4:Tm(0.3%)/LiGdF4 core/shell (C/S) UCNPs show small sizes ranging from 8.6 to 13.2 nm. Notably, 11.4 nm-sized C/S UCNPs show bright red light. Furthermore, LiErF4:Tm-based core/triple-shell (C/T-S) UCNPs are synthesized, and they show dramatic enhancement of red UCL (similar to 4242-fold enhancement compared with the core under 980 nm excitation and similar to 89-fold and similar to 14-fold enhancement compared with the C/S UCNPs under 800 and 1532 nm excitation, respectively). Besides UCL enhancement, Nd3+ ions doped in the LiErF4:Tm-based C/T-S UCNPs generate heat under 800 nm irradiation, allowing the C/T-S UCNPs to be applied as photothermal therapeutic agents. The ultrasmall (<20 nm) and bright red-emitting LiErF4:Tm-based C/T-S UCNPs have the potential for simultaneous imaging and photothermal therapeutic applications.
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