Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin
DC Field | Value | Language |
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dc.contributor.author | An, Jong Min | - |
dc.contributor.author | Moon, Heejo | - |
dc.contributor.author | Kim, Yejin | - |
dc.contributor.author | Kang, Sangrim | - |
dc.contributor.author | Kim, Youngseo | - |
dc.contributor.author | Jung, Yuna | - |
dc.contributor.author | Park, Sungnam | - |
dc.contributor.author | Verwilst, Peter | - |
dc.contributor.author | Kim, B. Moon | - |
dc.contributor.author | Kang, Jae Seung | - |
dc.contributor.author | Kim, Dokyoung | - |
dc.date.accessioned | 2021-08-30T14:05:33Z | - |
dc.date.available | 2021-08-30T14:05:33Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-09-14 | - |
dc.identifier.issn | 2050-7518 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53166 | - |
dc.description.abstract | We have explored a new research field of fluorophores through the manipulation of fluorophore-binding proteins. The development of a new imaging agent for tracing a specific organelle or a particular site within a living organism has been of great interest in the field of basic science as well as translational medicine. In this work and for the first time, we will disclose a new naphthalene-based dipolar dye and its complex, with serum albumin (SA), and show their applicability for the selective imaging of mitochondria in cells and the intestine in a mouse. The SA-binding dipolar dye, IPNHC, was synthesized straightforwardly, and we identified its photophysical properties and binding mode with SA. IPNHC-SA complex showed a bright emission in the blue wavelength range with a high quantum yield and stability. In the fluorescence imaging study, bright fluorescence images of mouse intestines were observed under a UV light, as well as two-photon (TP) deep tissue imaging after intravenous injection of IPNHC and IPNHC-SA complex. The present findings hold great promise for the application of the fluorescent complex for use in the tracing and tracking of intestine-related diseases at clinical sites. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | DRUG BINDING-SITES | - |
dc.subject | PROBES | - |
dc.subject | BOVINE | - |
dc.subject | EQUINE | - |
dc.subject | NANOPARTICLES | - |
dc.subject | STRATEGIES | - |
dc.subject | PROPERTY | - |
dc.subject | CELLS | - |
dc.title | Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungnam | - |
dc.identifier.doi | 10.1039/d0tb01314e | - |
dc.identifier.scopusid | 2-s2.0-85090510942 | - |
dc.identifier.wosid | 000565996500005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.8, no.34, pp.7642 - 7651 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 8 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | 7642 | - |
dc.citation.endPage | 7651 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | DRUG BINDING-SITES | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | BOVINE | - |
dc.subject.keywordPlus | EQUINE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | PROPERTY | - |
dc.subject.keywordPlus | CELLS | - |
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