Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adultCyfip2heterozygous mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Gyu Hyun | - |
dc.contributor.author | Zhang, Yinhua | - |
dc.contributor.author | Kang, Hyae Rim | - |
dc.contributor.author | Lee, Seung-Hyun | - |
dc.contributor.author | Shin, Jiwon | - |
dc.contributor.author | Lee, Chan Hee | - |
dc.contributor.author | Kang, Hyojin | - |
dc.contributor.author | Ma, Ruiying | - |
dc.contributor.author | Jin, Chunmei | - |
dc.contributor.author | Kim, Yoonhee | - |
dc.contributor.author | Kim, Su Yeon | - |
dc.contributor.author | Kwon, Seok-Kyu | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Lee, Kea Joo | - |
dc.contributor.author | Han, Kihoon | - |
dc.date.accessioned | 2021-08-30T14:05:57Z | - |
dc.date.available | 2021-08-30T14:05:57Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-09-11 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53170 | - |
dc.description.abstract | Variants of the cytoplasmic FMR1-interacting protein (CYFIP) gene family,CYFIP1andCYFIP2, are associated with numerous neurodevelopmental and neuropsychiatric disorders. According to several studies, CYFIP1 regulates the development and function of both pre- and post-synapses in neurons. Furthermore, various studies have evaluated CYFIP2 functions in the postsynaptic compartment, such as regulating dendritic spine morphology; however, no study has evaluated whether and how CYFIP2 affects presynaptic functions. To address this issue, in this study, we have focused on the presynapses of layer 5 neurons of the medial prefrontal cortex (mPFC) in adultCyfip2heterozygous (Cyfip2(+/-)) mice. Electrophysiological analyses revealed an enhancement in the presynaptic short-term plasticity induced by high-frequency stimuli inCyfip2(+/-)neurons compared with wild-type neurons. Since presynaptic mitochondria play an important role in buffering presynaptic Ca2+, which is directly associated with the short-term plasticity, we analyzed presynaptic mitochondria using electron microscopic images of the mPFC. Compared with wild-type mice, the number, but not the volume or cristae density, of mitochondria in both presynaptic boutons and axonal processes in the mPFC layer 5 ofCyfip2(+/-)mice was reduced. Consistent with an identification of mitochondrial proteins in a previously established CYFIP2 interactome, CYFIP2 was detected in a biochemically enriched mitochondrial fraction of the mouse mPFC. Collectively, these results suggest roles for CYFIP2 in regulating presynaptic functions, which may involve presynaptic mitochondrial changes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | CYFIP2 | - |
dc.subject | DENSITY | - |
dc.title | Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adultCyfip2heterozygous mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Kihoon | - |
dc.identifier.doi | 10.1186/s13041-020-00668-4 | - |
dc.identifier.scopusid | 2-s2.0-85090888131 | - |
dc.identifier.wosid | 000570690800001 | - |
dc.identifier.bibliographicCitation | MOLECULAR BRAIN, v.13, no.1 | - |
dc.relation.isPartOf | MOLECULAR BRAIN | - |
dc.citation.title | MOLECULAR BRAIN | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | CYFIP2 | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordAuthor | Presynapse | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | Medial prefrontal cortex | - |
dc.subject.keywordAuthor | Cytoplasmic FMR1-interacting protein 2 | - |
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