Ribosomal protein S3-derived repair domain peptides regulate UV-induced matrix metalloproteinase-1
DC Field | Value | Language |
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dc.contributor.author | Yang, Hee Woong | - |
dc.contributor.author | Jung, Youjin | - |
dc.contributor.author | Kim, Hag Dong | - |
dc.contributor.author | Kim, Joon | - |
dc.date.accessioned | 2021-08-30T14:43:42Z | - |
dc.date.available | 2021-08-30T14:43:42Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-09-10 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53175 | - |
dc.description.abstract | Ultraviolet (UV) radiation is a major factor that causes wrinkle formation by affecting the collagen level in the skin. Here, we show that a short peptide (A8) derived from the repair domain of the ribosomal protein S3 (rpS3) reduces UV irradiation-induced increase in matrix metalloproteinase-1 (MMP-1) and prevents collagen degradation by reducing the activation of the mitogen-activated protein kinase (MAPK) signaling proteins (extracellular signal-regulated kinase [ERK], p38, and c-Jun N-terminal kinases [JNK]) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) in cells. Furthermore, A8 also prevents the increase in the levels of inflammatory modulators such as tumor necrosis factor-alpha (TNF-alpha) or interleukin-6 (IL-6) in UV-irradiated cells. Collectively, our study suggests that the A8 peptide, derived from yeast or human, has anti-photoaging potential as it prevents UV-induced wrinkle formation. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ENDONUCLEASE ACTIVITY | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | HUMAN SKIN | - |
dc.subject | MECHANISMS | - |
dc.subject | S3 | - |
dc.subject | PREDICTION | - |
dc.subject | MAPK | - |
dc.subject | ACTIVATION | - |
dc.subject | RADIATION | - |
dc.title | Ribosomal protein S3-derived repair domain peptides regulate UV-induced matrix metalloproteinase-1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.06.094 | - |
dc.identifier.scopusid | 2-s2.0-85088659046 | - |
dc.identifier.wosid | 000565184300024 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.530, no.1, pp.149 - 154 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 530 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 149 | - |
dc.citation.endPage | 154 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ENDONUCLEASE ACTIVITY | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | HUMAN SKIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | S3 | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | MAPK | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordAuthor | rpS3 | - |
dc.subject.keywordAuthor | Photoaging | - |
dc.subject.keywordAuthor | MMP-1 | - |
dc.subject.keywordAuthor | Collagen | - |
dc.subject.keywordAuthor | MAPK/NF-kappa B pathway | - |
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