Renal hyperfiltration as a risk factor for chronic kidney disease: A health checkup cohort study
DC Field | Value | Language |
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dc.contributor.author | Oh, Se Won | - |
dc.contributor.author | Yang, Ji Hyun | - |
dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Cho, Won Yong | - |
dc.contributor.author | Jo, Sang Kyung | - |
dc.date.accessioned | 2021-08-30T14:45:33Z | - |
dc.date.available | 2021-08-30T14:45:33Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-09-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53190 | - |
dc.description.abstract | Introduction Renal hyperfiltration (RHF) has been found to be an independent predictor of adverse cardiovascular outcome. However, it remains uncertain whether it is precursor of chronic kidney disease (CKD) in a healthy population. Materials and methods To determine relative risks and identify the predictor of incident proteinuria and decline of estimated glomerular filtration rate (eGFR) in subjects with RHF. A total of 55,992 subjects aged >= 20 years who underwent health check-up during 2004-2017 were included. Among them, 16,946 subjects who completed at least two health checkups were analyzed. Results A total of 949 (5.6%) subjects developed proteinuria and 98 (0.6%) subjects showed >= 30% of eGFR decline. The risk of incident proteinuria was significantly higher in those with RHF (RR: 1.644; 95% CI: 1.064-2.541). Those with RHF showed 8.720 fold (95% CI: 4.205-18.081) increased risk for >= 30% decline. ESR, CRP, and monocyte count showed reversed J shaped curve according to the increase of eGFR. The adjusted mean of monocyte count was significantly higher in participants with eGFR >= 90ml/min/1.73m(2)or < 60ml/min/1.73m(2)compared to that in patients with eGFR 75-89ml/min/1.73m(2). Compared to subjects with the lowest tertile of monocyte and no RHF, those with the highest tertile of monocyte count in the RHF group had 3.314-fold (95% CI: 1.893-5.802) higher risk of incident proteinuria and 3.822-fold (95% CI, 1.327-11.006) risk of 30% eGFR decline. Conclusions RHF had significantly increased risk of developing proteinuria and CKD in healthy subjects. Higher monocyte count might be used as a predictor of CKD in subjects with RHF. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | GLOMERULAR HYPERFILTRATION | - |
dc.subject | MARKER | - |
dc.subject | ASSOCIATION | - |
dc.subject | OBESITY | - |
dc.title | Renal hyperfiltration as a risk factor for chronic kidney disease: A health checkup cohort study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Se Won | - |
dc.contributor.affiliatedAuthor | Kim, Myung-Gyu | - |
dc.contributor.affiliatedAuthor | Cho, Won Yong | - |
dc.contributor.affiliatedAuthor | Jo, Sang Kyung | - |
dc.identifier.doi | 10.1371/journal.pone.0238177 | - |
dc.identifier.scopusid | 2-s2.0-85090320786 | - |
dc.identifier.wosid | 000571063300036 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.15, no.9 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 15 | - |
dc.citation.number | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | GLOMERULAR HYPERFILTRATION | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | OBESITY | - |
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