Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeongshim | - |
dc.contributor.author | Shin, In-Soo | - |
dc.contributor.author | Kim, Woo C. | - |
dc.contributor.author | Yoon, Won S. | - |
dc.contributor.author | Koom, Woong S. | - |
dc.contributor.author | Rim, Chai H. | - |
dc.date.accessioned | 2021-08-30T15:10:59Z | - |
dc.date.available | 2021-08-30T15:10:59Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53263 | - |
dc.description.abstract | Background To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs >= 42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P = .011). The pooled rates of late grade >= 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. Conclusions Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | SQUAMOUS-CELL CARCINOMA | - |
dc.subject | 2ND PRIMARY HEAD | - |
dc.subject | HIGH-DOSE REIRRADIATION | - |
dc.subject | NASOPHARYNGEAL CARCINOMA | - |
dc.subject | DISEASE-CONTROL | - |
dc.subject | RADIOTHERAPY | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | SURVIVAL | - |
dc.subject | TRIAL | - |
dc.subject | PACLITAXEL | - |
dc.title | Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Won S. | - |
dc.contributor.affiliatedAuthor | Rim, Chai H. | - |
dc.identifier.doi | 10.1002/hed.26264 | - |
dc.identifier.scopusid | 2-s2.0-85085058286 | - |
dc.identifier.wosid | 000534381100001 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.42, no.9, pp.2473 - 2485 | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.citation.title | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.citation.volume | 42 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2473 | - |
dc.citation.endPage | 2485 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | 2ND PRIMARY HEAD | - |
dc.subject.keywordPlus | HIGH-DOSE REIRRADIATION | - |
dc.subject.keywordPlus | NASOPHARYNGEAL CARCINOMA | - |
dc.subject.keywordPlus | DISEASE-CONTROL | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordAuthor | head and neck cancer | - |
dc.subject.keywordAuthor | intensity-modulated radiotherapy | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | reirradiation | - |
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