Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Lymph node size and its association with nodal metastasis in ductal adenocarcinoma of the pancreas

Authors
Shin, JaehoonShin, SeungbeomLee, Jae HoonSong, Ki ByungHwang, Dae WookKim, Hyoung JungByun, Jae HoCho, HyungJunKim, Song CheolHong, Seung-Mo
Issue Date
9월-2020
Publisher
KOREAN SOC PATHOLOGISTS
Keywords
Pancreas; Neoplasms; Lymph node; Size; Metastasis
Citation
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, v.54, no.5, pp.387 - 395
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
Volume
54
Number
5
Start Page
387
End Page
395
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/53283
DOI
10.4132/jptm.2020.06.23
ISSN
2383-7837
Abstract
Background: Although lymph node metastasis is a poor prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC), our understanding of lymph node size in association with PDAC is limited. Increased nodal size in preoperative imaging has been used to detect node metastasis. We evaluated whether lymph node size can be used as a surrogate preoperative marker of lymph node metastasis. Methods: We assessed nodal size and compared it to the nodal metastatic status of 200 patients with surgically resected PDAC. The size of all lymph nodes and metastatic nodal foci were measured along the long and short axis, and the relationships between nodal size and metastatic status were compared at six cutoff points. Results: A total of 4,525 lymph nodes were examined, 9.1% of which were metastatic. The mean size of the metastatic nodes (long axis, 6.9 +/- 5.0 mm; short axis, 4.3 +/- 3.1 mm) was significantly larger than that of the non-metastatic nodes (long axis, 5.0 +/- 4.0 mm; short axis, 3.0 +/- 2.0 mm; all p<.001). Using a 10 mm cutoff, the sensitivity, specificity, positive predictive value, overall accuracy, and area under curve was 24.8%, 88.0%, 17.1%, 82.3%, and 0.60 for the long axis and 7.0%, 99.0%, 40.3%, 90.6%, and 0.61 for the short axis, respectively. Conclusions: The metastatic nodes are larger than the non-metastatic nodes in PDAC patients. However, the difference in nodal size was too small to be identified with preoperative imaging. The performance of preoperative radiologic imaging to predict lymph nodal metastasis was not good. Therefore, nodal size cannot be used a surrogate preoperative marker of lymph node metastasis.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Political Science & Economics > Department of Statistics > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher CHO, HYUNG JUN photo

CHO, HYUNG JUN
정경대학 (통계학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE