The Role of Sirtuins in Kidney Diseases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Yu Ah | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Jo, Minjee | - |
dc.contributor.author | Ko, Gang-Jee | - |
dc.date.accessioned | 2021-08-30T16:04:10Z | - |
dc.date.available | 2021-08-30T16:04:10Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53672 | - |
dc.description.abstract | Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sirtuins, SIRT1-7, and the diverse biological functions of each sirtuin are due to differences in subcellular localization, expression profiles, and cellular substrates. In this review, we summarize research advances into the role of sirtuins in the pathogenesis of various kidney diseases including acute kidney injury, diabetic kidney disease, renal fibrosis, and kidney aging along with the possible underlying molecular mechanisms. The available evidence indicates that sirtuins have great potential as novel therapeutic targets for the prevention and treatment of kidney diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ATTENUATES RENAL INJURY | - |
dc.subject | CALORIE RESTRICTION | - |
dc.subject | HISTONE DEACETYLASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | DIABETIC-NEPHROPATHY | - |
dc.subject | MITOCHONDRIAL SIRTUINS | - |
dc.subject | FIBROBLAST ACTIVATION | - |
dc.subject | GLUCOSE-HOMEOSTASIS | - |
dc.subject | NEGATIVE REGULATION | - |
dc.subject | MAMMALIAN SIR2 | - |
dc.title | The Role of Sirtuins in Kidney Diseases | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Minjee | - |
dc.contributor.affiliatedAuthor | Ko, Gang-Jee | - |
dc.identifier.doi | 10.3390/ijms21186686 | - |
dc.identifier.scopusid | 2-s2.0-85090548920 | - |
dc.identifier.wosid | 000580309100001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.18 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.citation.number | 18 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ATTENUATES RENAL INJURY | - |
dc.subject.keywordPlus | CALORIE RESTRICTION | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DIABETIC-NEPHROPATHY | - |
dc.subject.keywordPlus | MITOCHONDRIAL SIRTUINS | - |
dc.subject.keywordPlus | FIBROBLAST ACTIVATION | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | NEGATIVE REGULATION | - |
dc.subject.keywordPlus | MAMMALIAN SIR2 | - |
dc.subject.keywordAuthor | sirtuins | - |
dc.subject.keywordAuthor | kidney | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | diabetic nephropathy | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | aging kidney | - |
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