Remote Manipulation of Slidable Nano-Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages
- Authors
- Choi, Hyojun; Bae, Gunhyu; Khatua, Chandra; Min, Sunhong; Jung, Hee Joon; Li, Na; Jun, Indong; Liu, Hui-Wen; Cho, Youngkyu; Na, Kyu-Hwan; Ko, Minji; Shin, Hongchul; Kim, Yoon Hyuck; Chung, Seok; Song, Jae-Jun; Dravid, Vinayak P.; Kang, Heemin
- Issue Date
- 26-8월-2020
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- macrophage adhesion; macrophage polarization; macroscale ligand manipulation; reversible ligand sliding; slidable nano-ligand
- Citation
- ADVANCED FUNCTIONAL MATERIALS, v.30, no.35
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED FUNCTIONAL MATERIALS
- Volume
- 30
- Number
- 35
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/53733
- DOI
- 10.1002/adfm.202001446
- ISSN
- 1616-301X
- Abstract
- The development of materials capable of varying macroscale ligand distributions can emulate an extracellular matrix (ECM) remodeling and regulate the adhesion and polarization of macrophages. In this report, negatively charged slidable nano-ligands are assembled and then conjugated to a positively charged substrate via electrostatic interaction. The negatively charged slidable nano-ligands are prepared by coating magnetic nanoparticles with a polymer linker and negatively charged RGD ligand. The nano-ligand sliding is characterized under an external magnetic field, which spatiotemporally alters macroscale ligand density. To the best of knowledge, this is the first demonstration that magnetic maipulation of the macroscale ligand density inhibits inflammatory M1 phenotype but stimulates the adhesion and regenerative M2 phenotype of host macrophages. Furthermore, it is elucidated that the magnetic attraction of the slidable nano-ligand facilitates the assembly of adhesion structures in macrophages, thereby stimulating their regenerative M2 phenotype. The design of ECM-emulating materials that allow remote, spatiotemporal, and reversible controllability of macroscale ligand density provides an appealing strategy in the spatiotemporal regulation of immunomodulatory tissue-regenerative responses to implants in vivo.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
- College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.