Antioxidant and Antidiabetic Activities of Flavonoid Derivatives from the Outer Skins of Allium cepa L.
DC Field | Value | Language |
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dc.contributor.author | Ngoc Khanh Vu | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Manh Tuan Ha | - |
dc.contributor.author | Quynh-Mai Thi Ngo | - |
dc.contributor.author | Park, Se Eun | - |
dc.contributor.author | Kwon, Haeun | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Choi, Jae Sue | - |
dc.contributor.author | Kim, Jeong Ah | - |
dc.contributor.author | Min, Byung Sun | - |
dc.date.accessioned | 2021-08-30T16:13:02Z | - |
dc.date.available | 2021-08-30T16:13:02Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-08-19 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53747 | - |
dc.description.abstract | The onion, known as the bulb onion or common onion, is not only a key ingredient in many tasty and healthy vegetarian meals but also many traditional medicines. Nine new flavonoids [cepaflavas A, B (5, 6), cepadials A-D (7-9 and 14), and cepabiflas A-C (10-12)] and six known compounds (1-4, 13, 15) were obtained from the outer skins of Allium cepa L. Among them, compounds 5, 6, and 9 might be artificial products formed during extraction and isolation. New compounds were structurally elucidated using various spectroscopy/spectrometry techniques, including NMR and HRMS, and computational methods. Their absolute configurations were determined using time-dependent density functional theory calculations, combined with ECD spectroscopy, optical rotation calculation, and statistical procedures (CP3 and DP4 analysis). The free radical scavenging assays revealed that the new compounds 10-12 possessed considerable antioxidant activities with IC50 values of 4.25-8.88 and 7.12-8.14 mu M against DPPH and ABTS(center dot+), respectively. Compounds 13-15 showed substantial inhibitory activities against both alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B), with IC50 values of 0.89-6.80 and 1.13-6.82 mu M, respectively. On the basis of molecular docking studies, 13 and 15 were predicted to have high binding capacity and strong affinity toward the active site of PTP1B. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | CIRCULAR-DICHROISM | - |
dc.subject | GLYCOSIDES | - |
dc.subject | ONION | - |
dc.subject | PTP1B | - |
dc.subject | PHOSPHATASES | - |
dc.subject | FLOWERS | - |
dc.subject | LEAVES | - |
dc.title | Antioxidant and Antidiabetic Activities of Flavonoid Derivatives from the Outer Skins of Allium cepa L. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1021/acs.jafc.0c02122 | - |
dc.identifier.scopusid | 2-s2.0-85089712432 | - |
dc.identifier.wosid | 000563071500005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.68, no.33, pp.8797 - 8811 | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 68 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 8797 | - |
dc.citation.endPage | 8811 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | ONION | - |
dc.subject.keywordPlus | PTP1B | - |
dc.subject.keywordPlus | PHOSPHATASES | - |
dc.subject.keywordPlus | FLOWERS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordAuthor | Allium cepa skins | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | alpha-glucosidase | - |
dc.subject.keywordAuthor | PTP1B | - |
dc.subject.keywordAuthor | kinetic | - |
dc.subject.keywordAuthor | molecular docking | - |
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