Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island

Authors
Min, Seul KiKim, Jung EunHong, Ju-MiYim, Joung HanPark, HyunYoun, Ui JoungHan, Se JongKim, Il-Chan
Issue Date
8월-2020
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Keywords
Lecania gerlachei; lichens; Antarctica; antiinflammatory properties; nuclear factor kappa B (NF-kappa B) pathway
Citation
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.25, no.4, pp.543 - 550
Indexed
SCIE
SCOPUS
KCI
Journal Title
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
Volume
25
Number
4
Start Page
543
End Page
550
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/53866
DOI
10.1007/s12257-019-0371-4
ISSN
1226-8372
Abstract
Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei(LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1 beta and 1 alpha (IL-6, IL-1 beta and IL-1 alpha), and tumor necrosis factor alpha (TNF-alpha) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-kappa B) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE