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Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, Wenpei | - |
| dc.contributor.author | Song, Ziteng | - |
| dc.contributor.author | Wang, Huimei | - |
| dc.contributor.author | Yang, Xueyuan | - |
| dc.contributor.author | Joubert, Elizabeth | - |
| dc.contributor.author | Zhang, Jie | - |
| dc.contributor.author | Li, Shen | - |
| dc.contributor.author | Tuerhong, Muhetaer | - |
| dc.contributor.author | Abudukeremu, Munira | - |
| dc.contributor.author | Jin, Jin | - |
| dc.contributor.author | Xu, Jing | - |
| dc.contributor.author | Lee, Dongho | - |
| dc.contributor.author | Guo, Yuanqiang | - |
| dc.date.accessioned | 2021-08-30T18:04:25Z | - |
| dc.date.available | 2021-08-30T18:04:25Z | - |
| dc.date.created | 2021-06-19 | - |
| dc.date.issued | 2020-08 | - |
| dc.identifier.issn | 0045-2068 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/53868 | - |
| dc.description.abstract | A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-cler-odane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 mu M). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
| dc.subject | ANTI-NEUROINFLAMMATORY AGENTS | - |
| dc.subject | NEOCLERODANE DITERPENOIDS | - |
| dc.subject | INFLAMMATION | - |
| dc.subject | AD | - |
| dc.subject | MACROSPERMA | - |
| dc.subject | INHIBITORS | - |
| dc.title | Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Lee, Dongho | - |
| dc.identifier.doi | 10.1016/j.bioorg.2020.103966 | - |
| dc.identifier.scopusid | 2-s2.0-85086653127 | - |
| dc.identifier.wosid | 000552634300009 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC CHEMISTRY, v.101 | - |
| dc.relation.isPartOf | BIOORGANIC CHEMISTRY | - |
| dc.citation.title | BIOORGANIC CHEMISTRY | - |
| dc.citation.volume | 101 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | ANTI-NEUROINFLAMMATORY AGENTS | - |
| dc.subject.keywordPlus | NEOCLERODANE DITERPENOIDS | - |
| dc.subject.keywordPlus | INFLAMMATION | - |
| dc.subject.keywordPlus | AD | - |
| dc.subject.keywordPlus | MACROSPERMA | - |
| dc.subject.keywordPlus | INHIBITORS | - |
| dc.subject.keywordAuthor | Nitric oxide inhibitory effects | - |
| dc.subject.keywordAuthor | Ajuga pantantha | - |
| dc.subject.keywordAuthor | Diterpenoids | - |
| dc.subject.keywordAuthor | Inflammation | - |
| dc.subject.keywordAuthor | Molecular docking | - |
| dc.subject.keywordAuthor | Zebrafish model | - |
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