Amino Acid Metabolites and Slow Weight Loss in the Early Postoperative Period after Sleeve Gastrectomy
DC Field | Value | Language |
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dc.contributor.author | Kwon, Yeongkeun | - |
dc.contributor.author | Jang, Mi | - |
dc.contributor.author | Lee, Youngsun | - |
dc.contributor.author | Ha, Jane | - |
dc.contributor.author | Park, Sungsoo | - |
dc.date.accessioned | 2021-08-30T18:34:36Z | - |
dc.date.available | 2021-08-30T18:34:36Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54227 | - |
dc.description.abstract | Background: Profiles of amino acid metabolites (AAMs) have been linked to obesity and energy homeostasis. We investigated whether baseline obesity-related AAMs were associated with weight status in the early postoperative period after sleeve gastrectomy. Methods: In this prospective, single-arm, longitudinal study, 27 bariatric patients underwent sleeve gastrectomy. Twenty obesity-related AAMs were comprehensively quantified prior to surgery, and slow weight loss was defined as the lowest 40% of the percentage excess weight loss (%EWL) at three and six months postoperatively. Linear regression models were used to assess the association between baseline obesity-related AAMs and %EWL, and receiver operating characteristic curves were assessed. Results: Isoleucine and metabolites from the serotonin pathway were significantly associated with the %EWL at three and six months after sleeve gastrectomy. Among the metabolites identified to be significant in the regression analyses, serotonin (area under receiver operating characteristic curves (AUROC): 0.79, 95% confidence interval (CI): 0.59-0.97) and serotonin/5-hydroxytryptophan ratio (AUROC: 0.80, 95% CI: 0.58-1.00) showed superior performance in predicting slow weight loss six months after sleeve gastrectomy. Conclusions: Our findings underscore the importance of baseline AAM profiles, especially serotonin and serotonin/5-hydroxytryptophan ratio, in predicting slow weight loss in the early postoperative period after sleeve gastrectomy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | Y GASTRIC BYPASS | - |
dc.subject | BARIATRIC SURGERY | - |
dc.subject | PERIPHERAL SEROTONIN | - |
dc.subject | SEVERE OBESITY | - |
dc.subject | HEALTH | - |
dc.subject | PROTEIN | - |
dc.subject | METAANALYSIS | - |
dc.subject | ISOLEUCINE | - |
dc.subject | OUTCOMES | - |
dc.subject | LIFE | - |
dc.title | Amino Acid Metabolites and Slow Weight Loss in the Early Postoperative Period after Sleeve Gastrectomy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Yeongkeun | - |
dc.contributor.affiliatedAuthor | Park, Sungsoo | - |
dc.identifier.doi | 10.3390/jcm9082348 | - |
dc.identifier.wosid | 000568148500001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.9, no.8 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | Y GASTRIC BYPASS | - |
dc.subject.keywordPlus | BARIATRIC SURGERY | - |
dc.subject.keywordPlus | PERIPHERAL SEROTONIN | - |
dc.subject.keywordPlus | SEVERE OBESITY | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | ISOLEUCINE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordAuthor | amino acid | - |
dc.subject.keywordAuthor | metabolomics | - |
dc.subject.keywordAuthor | sleeve gastrectomy | - |
dc.subject.keywordAuthor | bariatric surgery | - |
dc.subject.keywordAuthor | weight loss | - |
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