Can moderate-intensity aerobic exercise ameliorate atopic dermatitis?
- Authors
- Son, Wang Kuk; Yoon, Wonsuck; Kim, Seunghyun; Byeon, Jung Hye; Lee, Jue Seong; Kim, Dasarang; Jaehoon, Lim; Chae, Yangseok; Yoon, Sung Jin; Yoo, Young
- Issue Date
- 8월-2020
- Publisher
- WILEY
- Keywords
- aerobic exercise; atopic dermatitis; immunoglobulin E; macrophage-derived chemokine; monocyte chemotactic protein-1
- Citation
- EXPERIMENTAL DERMATOLOGY, v.29, no.8, pp.699 - 702
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERIMENTAL DERMATOLOGY
- Volume
- 29
- Number
- 8
- Start Page
- 699
- End Page
- 702
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54231
- DOI
- 10.1111/exd.14138
- ISSN
- 0906-6705
- Abstract
- It has been shown that aerobic exercise improves atopic dermatitis (AD), although the mechanism is not clear. Here, we propose a hypothesis that moderate-intensity aerobic exercise improves AD in a mouse model through modulating allergic inflammation. The DNCB-treated mouse model for eczema was divided into 3 groups: (a) not subjected to aerobic exercise, (b) subjected to continuous aerobic exercise and (c) subjected to accumulated aerobic exercise. After given exercise using a treadmill device either 30 min/d or 10 min x 3/day at a speed of 16 m/min, for 9 days, respectively, dermatitis symptom score, thickness of epidermis/dermis and eosinophil infiltration were decreased in the 2 exercise groups compared to the sedentary living group. The serum levels of IgE, MCP-1 and MDC showed a significant decrease both in the continuous or accumulated exercise groups. Moderate-intensity aerobic exercise ameliorates dermatitis symptoms through immune modulation in the DNCB-treated mouse model for eczema.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- College of Education > Department of Physical Education > 1. Journal Articles
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