A Prospective Randomized Clinical Trial of Combination Therapy with Proton Pump Inhibitors and Mucolytics in Patients with Laryngopharyngeal Reflux
DC Field | Value | Language |
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dc.contributor.author | Chae, Minsuk | - |
dc.contributor.author | Jang, Dong Hyuk | - |
dc.contributor.author | Kim, Ho Chan | - |
dc.contributor.author | Kwon, Minsu | - |
dc.date.accessioned | 2021-08-30T18:36:42Z | - |
dc.date.available | 2021-08-30T18:36:42Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0003-4894 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54246 | - |
dc.description.abstract | Objectives: To identify whether combination therapy with mucolytics and proton pump inhibitors (PPIs) leads to faster and more effective symptomatic relief in patients with laryngopharyngeal reflux (LPR). Methods: Patients diagnosed as LPR with a reflux symptom index (RSI) >= 13 and a reflux finding score (RFS) >= 7 were enrolled in this prospective study. Patients were randomly allocated to control (PPI only) or experimental (PPI + mucolytics) groups and changes in RSI and RFS values were assessed at 1- and 3-month follow-up. Results: One hundred sixteen patients were randomly allocated into either the control group (n = 59) or the experimental group (n = 57). The RSI and RFS scores significantly decreased in both groups (all P < .001) after 1 month of treatment; however, there was no significant difference in RSI change between groups (P = .223). After 3 months of treatment, there remained no significant difference in RSI change between groups (P = .592). Conclusions: Combination therapy with mucolytics and PPI compared to PPI alone did not lead to faster or more effective symptomatic relief in LPR patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.subject | FINDING SCORE | - |
dc.subject | RELIABILITY | - |
dc.subject | SYMPTOMS | - |
dc.subject | VALIDITY | - |
dc.subject | PH | - |
dc.title | A Prospective Randomized Clinical Trial of Combination Therapy with Proton Pump Inhibitors and Mucolytics in Patients with Laryngopharyngeal Reflux | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Minsu | - |
dc.identifier.doi | 10.1177/0003489420913592 | - |
dc.identifier.scopusid | 2-s2.0-85082101586 | - |
dc.identifier.wosid | 000523855500001 | - |
dc.identifier.bibliographicCitation | ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, v.129, no.8, pp.781 - 787 | - |
dc.relation.isPartOf | ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | - |
dc.citation.title | ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | - |
dc.citation.volume | 129 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 781 | - |
dc.citation.endPage | 787 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | FINDING SCORE | - |
dc.subject.keywordPlus | RELIABILITY | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | VALIDITY | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordAuthor | ambroxol-theophyllin-7-acetate | - |
dc.subject.keywordAuthor | globus sensation | - |
dc.subject.keywordAuthor | laryngopharyngeal reflux | - |
dc.subject.keywordAuthor | expectorants | - |
dc.subject.keywordAuthor | proton pump inhibitors | - |
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