Rogue cell-like chromosomal aberrations in peripheral blood lymphocytes of interventional radiologists: A case study
- Authors
- Jang, Seongjae; Lee, Younghyun; Songwon, Seo; Jin, Young Woo; Lee, Won-Jin
- Issue Date
- 8월-2020
- Publisher
- ELSEVIER
- Keywords
- Dicentrics; Occupational exposure; Radiation protection; Dose monitoring; Fluoroscopy procedures
- Citation
- MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v.856
- Indexed
- SCIE
SCOPUS
- Journal Title
- MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Volume
- 856
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54269
- DOI
- 10.1016/j.mrgentox.2020.503234
- ISSN
- 1383-5718
- Abstract
- We report two cases of interventional radiologists who had been exposed to radiation while performing fluoroscopically-guided interventional procedures (FGIPs), mainly transcatheter arterial chemoembolization, percutaneous catheter drainage, and percutaneous transhepatic biliary drainage procedures, for over 10 years. They had a unique multi-aberrant cell type with not only high numbers of dicentrics and/or centric rings but also excess acentric double minutes, similar to a rogue cell. As revealed in a self-administered questionnaire, they wore personal dosimeters and protective equipment at all times and used shielding devices during interventional fluoroscopy procedures. However, the exposed dose levels derived from cytogenetic dosimetry were much higher than the doses recorded on their personal dosimeters. A large number of unstable and stable chromosomal aberrations that were found in the peripheral blood lymphocytes of these interventional radiologists might be due to repeated and long-term exposure to ionizing radiation while performing FGIPs. Further investigations of chromosomal aberrations in interventional radiologists may improve the understanding of the long-term effects of radiation exposure on medical personnel.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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