The Protective Effect of an Eye Wash Solution on the Ocular Surface Damage Induced by Airborne Carbon Black Exposure
DC Field | Value | Language |
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dc.contributor.author | Li, Xiangzhe | - |
dc.contributor.author | Kang, Boram | - |
dc.contributor.author | Eom, Youngsub | - |
dc.contributor.author | Lee, Hyung Keun | - |
dc.contributor.author | Kim, Hyo Myung | - |
dc.contributor.author | Song, Jong Suk | - |
dc.date.accessioned | 2021-08-30T18:46:25Z | - |
dc.date.available | 2021-08-30T18:46:25Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0277-3740 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54282 | - |
dc.description.abstract | Purpose: To investigate the effects of an eye wash solution on the ocular surface damage induced by airborne carbon black (CB) exposure. Methods: Sprague-Dawley rats were exposed to ambient CB for 5 days. During the 5 days, a commercial eye wash solution (Eyebon-W) was used for irrigation twice daily on CB-exposed rat eyes; normal saline was used as the vehicle control. Lactic dehydrogenase (LDH) activity and matrix metallopeptidase (MMP)-9, histamine, and lactoferrin levels were measured in tears. The expression of inflammatory cytokines in the anterior segment of the eyeball was measured by Western blot analysis. Results: The ocular surface staining scores, tear LDH activity, tear MMP-9, histamine, and lactoferrin concentrations, and the expression of interleukin-4 and interferon-gamma in the eye were significantly increased in the CB group versus the normal control group. When compared with CB group, the Eyebon-W eye wash treatment significantly reversed these elevations induced by CB, including ocular staining scores, tear LDH activity, histamine and MMP-9 concentrations in the tear fluid, and the expression of interleukin-4 in the eye. On the other hand, saline irrigation only reduced the concentrations of histamine and MMP-9 in tear fluid and the expression of interferon-gamma in the eye. Conclusions: Both Eyebon-W eye wash treatment and saline irrigation reversed CB-induced ocular surface injury, but the efficacy of Eyebon-W was more significant than that of the saline solution when compared with CB group. The use of an eye wash solution seems to play a protective role for the ocular surface when exposed to airborne particulate matter. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | AIR-POLLUTION | - |
dc.subject | CONJUNCTIVITIS | - |
dc.subject | LACTOFERRIN | - |
dc.subject | EXPRESSION | - |
dc.title | The Protective Effect of an Eye Wash Solution on the Ocular Surface Damage Induced by Airborne Carbon Black Exposure | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eom, Youngsub | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Myung | - |
dc.contributor.affiliatedAuthor | Song, Jong Suk | - |
dc.identifier.doi | 10.1097/ICO.0000000000002304 | - |
dc.identifier.scopusid | 2-s2.0-85087533766 | - |
dc.identifier.wosid | 000559736500023 | - |
dc.identifier.bibliographicCitation | CORNEA, v.39, no.8, pp.1040 - 1047 | - |
dc.relation.isPartOf | CORNEA | - |
dc.citation.title | CORNEA | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1040 | - |
dc.citation.endPage | 1047 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | CONJUNCTIVITIS | - |
dc.subject.keywordPlus | LACTOFERRIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | air pollution | - |
dc.subject.keywordAuthor | carbon black | - |
dc.subject.keywordAuthor | particulate matter | - |
dc.subject.keywordAuthor | ocular surface damage | - |
dc.subject.keywordAuthor | eye wash solution | - |
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