Radiologic-Pathologic Correlation of Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement at Gadoxetic Acid-enhanced MRI: A Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | Joo, Ijin | - |
dc.contributor.author | Kim, So Yeon | - |
dc.contributor.author | Kang, Tae Wook | - |
dc.contributor.author | Kim, Young Kon | - |
dc.contributor.author | Park, Beom Jin | - |
dc.contributor.author | Lee, Yoon Jin | - |
dc.contributor.author | Choi, Joon-Il | - |
dc.contributor.author | Lee, Chang-Hee | - |
dc.contributor.author | Park, Hee Sun | - |
dc.contributor.author | Lee, Kyoungbun | - |
dc.contributor.author | Kim, Haeryoung | - |
dc.contributor.author | Yu, Eunsil | - |
dc.contributor.author | Kang, Hyo Jeong | - |
dc.contributor.author | Ha, Sang Yun | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Ahn, Soomin | - |
dc.contributor.author | Jung, Eun Sun | - |
dc.contributor.author | Kim, Baek-Hui | - |
dc.contributor.author | Han, Hye Seung | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.date.accessioned | 2021-08-30T18:48:19Z | - |
dc.date.available | 2021-08-30T18:48:19Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54299 | - |
dc.description.abstract | Background: Hepatobiliary phase (HBP) hypointense nodules without arterial phase hyper enhancement (APHE) at gadoxetic acid enhanced MRI may indicate hepatocellular carcinoma (HCC) or nonmalignant cirrhosis-associated nodules. Purpose: To assess the distribution of pathologic diagnoses of HBP hypointense nodules without APHE at gadoxetic acid-enhanced MRI and to evaluate clinical and imaging features in differentiating their histologic grades. Materials and Methods: This retrospective multicenter study included pathologic analysis-confirmed HBP hypointense nodules without APHE (<= 30 mm) in patients with chronic liver disease or cirrhosis screened between January 2008 and June 2016. Central pathologic review by 10 pathologists determined final histologic grades as progressed HCC, early HCC, high-grade dysplastic nodule (DN), and low-grade DN or regenerative nodule. Gadoxetic acid-enhanced MRI features were analyzed by three radiologists. Multivariable logistic regression analyses with elastic net regularization were performed to identify clinical and imaging features for differentiating histologic grades. Results: There were 298 patients (mean age, 59 years +/- 10; 226 men) with 334 nodules evaluated, and progressed HCCs were diagnosedin 44.0% (147 of 334), early HCCs in 20.4% (68 of 334), high-grade DNs in 27.5% (92 of 334), and low-grade DNs orregenerative nodules in 8.1% (27 of 334). Serum alpha-fetoprotein level 100 ng/mL or greater (odds ratio, 2.7; P =.01) and MRI features including well-defined margin (odds ratio, 5.5; P =.003), hypointensity at precontrast T1-weighted imaging (odds ratio, 3.2;P <.001), intermediate hyperintensity at T2-weighted imaging (odds ratio, 3.4; P <.001), and restricted diffusion (odds ratio, 1.9; P =.04) were independent predictors for progressed HCC at multivariable analysis. Conclusion: In patients at high risk for hepatocellular carcinoma (HCC), hepatobiliary phase hypointense nodules without arterial phase hyperenhancement at gadoxetic acid-enhanced MRI corresponded mainly to progressed HCCs, early HCCs, and high-grade dysplasticnodules. High alpha-fetoprotein level and some imaging features at MRI helped to differentiate progressed HCC from lower grade nodules. (C) RSNA, 2020 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | RADIOLOGICAL SOC NORTH AMERICA | - |
dc.subject | EARLY HEPATOCELLULAR-CARCINOMA | - |
dc.subject | DIAGNOSTIC PERFORMANCE | - |
dc.subject | HEPATIC NODULES | - |
dc.subject | RISK | - |
dc.subject | CT | - |
dc.subject | RECURRENCE | - |
dc.subject | FEATURES | - |
dc.subject | LESIONS | - |
dc.subject | IMAGES | - |
dc.subject | HCC | - |
dc.title | Radiologic-Pathologic Correlation of Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement at Gadoxetic Acid-enhanced MRI: A Multicenter Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Beom Jin | - |
dc.contributor.affiliatedAuthor | Lee, Chang-Hee | - |
dc.contributor.affiliatedAuthor | Kim, Baek-Hui | - |
dc.identifier.doi | 10.1148/radiol.2020192275 | - |
dc.identifier.scopusid | 2-s2.0-85088495752 | - |
dc.identifier.wosid | 000551892700043 | - |
dc.identifier.bibliographicCitation | RADIOLOGY, v.296, no.2, pp.335 - 345 | - |
dc.relation.isPartOf | RADIOLOGY | - |
dc.citation.title | RADIOLOGY | - |
dc.citation.volume | 296 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 335 | - |
dc.citation.endPage | 345 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | EARLY HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | DIAGNOSTIC PERFORMANCE | - |
dc.subject.keywordPlus | HEPATIC NODULES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | IMAGES | - |
dc.subject.keywordPlus | HCC | - |
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