Heat-Generating Iron Oxide Multigranule Nanoclusters for Enhancing Hyperthermic Efficacy in Tumor Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Sangmin | - |
dc.contributor.author | Park, Bum Chul | - |
dc.contributor.author | Lim, Seungho | - |
dc.contributor.author | Yoon, Hong Yeol | - |
dc.contributor.author | Jeon, Yoo Sang | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.date.accessioned | 2021-08-30T18:52:13Z | - |
dc.date.available | 2021-08-30T18:52:13Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-07-29 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54336 | - |
dc.description.abstract | The development of heat-generating magnetic nanostructures is critical for the effective management of tumors using magnetic hyperthermia. Herein, we demonstrate that polyethylene glycol (PEG)-coated iron oxide (magnetite, Fe3O4) multigranule nanoclusters (PEG-MGNCs) can enhance the efficiency of hyperthermia-based tumor suppression in vitro and in vivo. MGNCs consisting of granules (crystallites) measuring 22.9 nm in diameter were prepared via the hydrothermal polyol method, followed by the surface modification of MGNCs with PEG-dopamine. The freshly prepared PEG-MGNCs exhibit 145.9 +/- 10.2 nm diameter on average under aqueous conditions. The three-dimensional structures of PEG-MGNCs enhance the hyperthermic efficacy compared with PEGylated single iron-oxide nanoparticles (NPs), resulting in severe heat damage to tumor cells in vitro. In the SCC7 tumor-bearing mice, near-infrared fluorescence dye (Cy5.5)-labeled PEG-MGNCs are successfully accumulated in the tumor tissues because of NP-derived enhanced permeation and retention effect. Finally, the tumor growth is significantly suppressed in PEG-MGNC-treated mice after two-times heat generation by using a longitudinal solenoid, which can generate an alternating magnetic field under high-frequency (19.5 kA/m, 389 kHz) induction. This study shows for the first time that the PEG-MGNCs greatly enhance the hyperthermic efficacy of tumor treatment both in vitro and in vivo. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | MAGNETIC NANOPARTICLES | - |
dc.subject | SIZE | - |
dc.subject | DESIGN | - |
dc.subject | IMPACT | - |
dc.subject | MRI | - |
dc.subject | ACCUMULATION | - |
dc.subject | MECHANISMS | - |
dc.subject | PRINCIPLES | - |
dc.subject | EFFICIENCY | - |
dc.subject | NANOCUBES | - |
dc.title | Heat-Generating Iron Oxide Multigranule Nanoclusters for Enhancing Hyperthermic Efficacy in Tumor Treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Keun | - |
dc.contributor.affiliatedAuthor | Kim, Kwangmeyung | - |
dc.identifier.doi | 10.1021/acsami.0c07419 | - |
dc.identifier.scopusid | 2-s2.0-85089707778 | - |
dc.identifier.wosid | 000557854700004 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.12, no.30, pp.33483 - 33491 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 12 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 33483 | - |
dc.citation.endPage | 33491 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PRINCIPLES | - |
dc.subject.keywordPlus | EFFICIENCY | - |
dc.subject.keywordPlus | NANOCUBES | - |
dc.subject.keywordAuthor | hyperthermia | - |
dc.subject.keywordAuthor | high frequency | - |
dc.subject.keywordAuthor | theranostic | - |
dc.subject.keywordAuthor | iron oxide nanoparticle | - |
dc.subject.keywordAuthor | multigranule nanocluster | - |
dc.subject.keywordAuthor | polyethylene glycol | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.