Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Da Young | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Yu, Ji Hee | - |
dc.contributor.author | Park, Sanghyun | - |
dc.contributor.author | Heo, Jee-In | - |
dc.contributor.author | Seo, Ji A. | - |
dc.contributor.author | Kim, Nam Hoon | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.contributor.author | Kim, Seon Mee | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Park, Yong Gyu | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.date.accessioned | 2021-08-30T19:15:57Z | - |
dc.date.available | 2021-08-30T19:15:57Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-07-15 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54384 | - |
dc.description.abstract | The aim of this study is to investigate whether GGT variability is able to predict the risk of end-stage renal disease (ESRD). The study subjects were Koreans who conducted health exams supported by the Korean National Health Insurance Corporation during 2009-2012 (baseline). After excluding individuals aged<40 years, heavy alcoholics, or those with histories of chronic liver disease or ESRD, we followed 6,058,995 individuals. We calculated the average successive variability (ASV) of GGT values during the 5 years before the baseline as a parameter of variability. Using Cox proportional analyses, we evaluated the risk of ESRD according to GGT ASV quartiles, defined as the initiation of renal replacement therapy or kidney transplantation, or December 31, 2016. During 38,663,279.3 person-years of follow-up, 12,057 cases of ESRD were identified. Compared with GGT ASV quartile 1, the risk of ESRD was higher in ASV quartiles 3-4 and increased serially, even after adjustment for several metabolic parameters, baseline renal function, presence of comorbidities, low income, and baseline GGT and hemoglobin level. The fully adjusted hazard ratios (95% confidence intervals) of GGT ASV quartiles 3 and 4 were 1.06 (1.01-1.12) and 1.12 (1.06-1.18), respectively. In conclusion, GGT variability is a putative risk factor for ESRD in Koreans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CHRONIC KIDNEY-DISEASE | - |
dc.subject | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | LIVER-FUNCTION | - |
dc.subject | RISK-FACTOR | - |
dc.subject | INDIVIDUALS | - |
dc.subject | CHOLESTEROL | - |
dc.subject | FRACTIONS | - |
dc.subject | MORTALITY | - |
dc.subject | ESRD | - |
dc.title | Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Da Young | - |
dc.contributor.affiliatedAuthor | Yu, Ji Hee | - |
dc.contributor.affiliatedAuthor | Seo, Ji A. | - |
dc.contributor.affiliatedAuthor | Kim, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.contributor.affiliatedAuthor | Kim, Seon Mee | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.identifier.doi | 10.1038/s41598-020-68603-0 | - |
dc.identifier.scopusid | 2-s2.0-85088031027 | - |
dc.identifier.wosid | 000550032800002 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | LIVER-FUNCTION | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | FRACTIONS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | ESRD | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.