Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hee-Kyung | - |
dc.contributor.author | Lee, Jung-Jin | - |
dc.contributor.author | Choi, Garam | - |
dc.contributor.author | Sung, Bokyung | - |
dc.contributor.author | Kim, Yeoun-Hee | - |
dc.contributor.author | Baek, Ah Rum | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Song, Huijin | - |
dc.contributor.author | Kim, Minsup | - |
dc.contributor.author | Cho, Art E. | - |
dc.contributor.author | Lee, Gang Ho | - |
dc.contributor.author | Moon, Sungjun | - |
dc.contributor.author | Kang, Min-Kyoung | - |
dc.contributor.author | Lee, Jae Jun | - |
dc.contributor.author | Chang, Yongmin | - |
dc.date.accessioned | 2021-08-30T19:37:34Z | - |
dc.date.available | 2021-08-30T19:37:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-07-09 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54409 | - |
dc.description.abstract | Advancements in recanalization therapies have rendered reperfusion injury an important challenge for stroke management. It is essential to work toward effective therapeutics that protect the ischemic brain from reperfusion injury. Here, we report a new concept of neuroprognostic agents, which combine molecular diagnostic imaging and targeted neuroprotection for treatment of reperfusion injury after stroke. These neuroprognostic agents are inflammation-targeted gadolinium compounds conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs). Our results demonstrated that gadolinium-based MRI contrast agents conjugated with NSAIDs suppressed the increase in cyclooxygenase-2 (COX-2) levels, ameliorated glial activation, and neuron damage that are phenotypic for stroke by mitigating neuroinflammation, which prevented reperfusion injury. In addition, this study showed that the neuroprognostic agents are promising T(1 )molecular MRI contrast agents for detecting precise reperfusion injury locations at the molecular level. Our results build on this new concept of neuroprognostics as a novel management strategy for ischemia-reperfusion injury, combining neuroprotection and molecular diagnostics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | CEREBRAL-ISCHEMIA | - |
dc.subject | NEUROPROTECTION | - |
dc.subject | MECHANISMS | - |
dc.subject | MRI | - |
dc.subject | PATHOPHYSIOLOGY | - |
dc.subject | ACTIVATION | - |
dc.subject | DAMAGE | - |
dc.subject | DEATH | - |
dc.subject | RAT | - |
dc.title | Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Art E. | - |
dc.identifier.doi | 10.1021/acs.jmedchem.0c00285 | - |
dc.identifier.scopusid | 2-s2.0-85088207356 | - |
dc.identifier.wosid | 000550753700022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL CHEMISTRY, v.63, no.13, pp.6909 - 6923 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 63 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 6909 | - |
dc.citation.endPage | 6923 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | NEUROPROTECTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | RAT | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.