Circulating Interleukin-37 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Correlations With Disease Activity: A Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-08-30T19:49:18Z | - |
dc.date.available | 2021-08-30T19:49:18Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54486 | - |
dc.description.abstract | Objective. To assess the circulating levels of interleukin (IL)-37 in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and determine a correlation between plasma/serum IL-37 levels and disease activity. Methods. We performed a meta-analysis comparing plasma/serum IL-37 level between patients with RA or SLE and controls, and examined correlation coefficients between circulating IL-37 levels and disease activity. Results. A total of 14 publications included 711 patients with RA and 394 controls, 522 patients with SLE and 259 controls. In the RA group, the IL-37 level was significantly higher than in the control group (standardized mean difference [SMD]=1.222, 95% confidence interval [CI]=0.722 similar to 1.711, p<0.001). Subgroup analysis by sample size showed a significantly higher IL-37 level in RA group of large (n>90) and small sample numbers (n <= 90) (SMD=0.994, 95% CI=0.323 similar to 1.666, p<0.001; SMD=1.617, 95% CI=1.328 similar to 1.906, p<0.001). In addition, IL-37 level in SLE group was significantly higher than in control group (SMD=1.096, 95% CI=0.635 similar to 1.558, p<0.001). A strong association between circulating IL-37-level and RA activity based on Disease activity Score 28 was shown (correlation coefficients=0.547, 95% CI=0.355 similar to 0.695, p<0.001). Meta-analysis of the coefficients for correlation indicated a positive correlation between the circulating level of IL-37 and SLE activity based on Systemic Lupus Erythematosus Disease Activity Index (coefficients for correlation<0.588, 95 % CI= 0.270 similar to 0.806, p=0.003). Conclusion. Our meta-analysis showed that circulating IL-37 levels are higher in RA and SLE patients, and there is a positive correlation between IL-37 and disease activity in RA and SLE. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN COLL RHEUMATOLOGY | - |
dc.subject | ELEVATED SERUM | - |
dc.subject | IL-37 | - |
dc.subject | CYTOKINES | - |
dc.title | Circulating Interleukin-37 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Correlations With Disease Activity: A Meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.4078/jrd.2020.27.3.152 | - |
dc.identifier.wosid | 000549290000004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATIC DISEASES, v.27, no.3, pp.152 - 158 | - |
dc.relation.isPartOf | JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.title | JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 152 | - |
dc.citation.endPage | 158 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002602673 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | ELEVATED SERUM | - |
dc.subject.keywordPlus | IL-37 | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordAuthor | IL37 protein | - |
dc.subject.keywordAuthor | human | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
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