Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study
- Authors
- Jung, Jongheon; Choi, Yoon Seok; Lee, Jae Hoon; Lee, Won Sik; Kim, Sung-hyun; Park, Yong; Lee, Seung-Shin; Do, Young Rok; Jo, Jae-Cheol; Lee, Je-Jung; Kim, Jin Seok; Shin, Ho-Jin; Shin, Dong-Yeop; Yoon, Sung-Soo; Min, Chang-Ki; Kim, Kihyun; Eom, Hyeon-Seok
- Issue Date
- 7월-2020
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Multiple myeloma; Autologous; Stem cell; Transplantation; Elderly
- Citation
- INTERNATIONAL JOURNAL OF HEMATOLOGY, v.112, no.1, pp.84 - 95
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Volume
- 112
- Number
- 1
- Start Page
- 84
- End Page
- 95
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54502
- DOI
- 10.1007/s12185-020-02869-y
- ISSN
- 0925-5710
- Abstract
- Autologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age >= 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age >= 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to ASCT was 6.3 months. Complete response plus stringent complete response rate increased from 36 (24.0%) to 105 (70.0%) after ASCT, and high-quality response (>= very good partial response) increased from 96 (64.0%) to 125 (83.3%). With a median follow-up of 32.6 months after ASCT, 5-year OS and PFS were 59.7% and 22.8%, respectively. Febrile neutropenia occurred in 43.5%, and nausea (21.3%) and stomatitis (13.2%) were common grade 3-4 non-hematologic adverse events. Of 44 deaths, disease progression (n = 23) was the most common cause of mortality, followed by infection (n = 13). Treatment-related death occurred in four cases (2.7%). ASCT is an effective and safe option for elderly MM patients and is associated with superior clinical outcomes.
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