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Prognostic Value ofCD200R1mRNA Expression in Head and Neck Squamous Cell Carcinoma

Authors
Chang, HyunLee, Yun-GyooKo, Yoon HoCho, Jang HoChoi, Jong-KwonPark, Keon UkKang, Eun JooLee, Keun-WookLim, Sun MinKim, Jin-SooLee, Hyun WooKim, Min KyoungHwang, In GyuKim, SangwooNam, Byung-HoKim, Hye Ryun
Issue Date
7월-2020
Publisher
MDPI
Keywords
mRNA expression; prognosis; immune cell; head and neck cancer
Citation
CANCERS, v.12, no.7
Indexed
SCIE
SCOPUS
Journal Title
CANCERS
Volume
12
Number
7
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/54875
DOI
10.3390/cancers12071777
ISSN
2072-6694
Abstract
Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250).CD200R1was identified as an independent prognostic factor and validated in GEO and TCGA database.CD2000R1mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover,CD200R1was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated withCD200R1expression. Samples with higherCD200R1expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy.
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