Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Dual peptide-dendrimer conjugate inhibits acetylation of transforming growth factor beta-induced protein and improves survival in sepsis

Authors
Lee, WonhwaPark, Eun JiKwon, Oh KwangKim, HyelimYoo, YoungbumKim, Shin-WooSeo, Young-KyoKim, In-SanNa, Dong HeeBae, Jong-Sup
Issue Date
7월-2020
Publisher
ELSEVIER SCI LTD
Keywords
Sepsis; Transforming growth factor beta-induced protein; Acetylation inhibitory peptide; Dendrimer; Nanodrug delivery
Citation
BIOMATERIALS, v.246
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
246
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/54903
DOI
10.1016/j.biomaterials.2020.120000
ISSN
0142-9612
Abstract
Sepsis is a potentially fatal complication of infections and there are currently no effective therapeutic options for severe sepsis. In this study, we revealed the secretion mechanism of transforming growth factor beta-induced protein (TGFBIp) that was recently identified as a therapeutic target for sepsis, and designed TGFBIp acetylation inhibitory peptide (TAIP) that suppresses acetylation of lysine 676 in TGFBIp. To improve bioavailability and biodegradation of the peptide, TAIP was conjugated to polyamidoamine (PAMAM) dendrimers. Additionally, the cell-penetrating peptide (CPP) was conjugated to the TAIP-modified PAMAM dendrimers for the intracellular delivery of TGFBIp. The resulting nanostructures, decorated with TAIP and CPP via poly(ethylene glycol) linkage, improved the mortality and organ damage in the septic mouse model and suppressed lipopolysaccharide-activated severe vascular inflammatory responses in endothelial cells. Thus, the dendrimer-based nanostructures for delivery of TAIP using CPP show great promise in practical applications in sepsis therapy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE