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Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents

Authors
Im, Seung HyukPark, Su JeongJung, YoungmeeChung, Justin J.Kim, Soo Hyun
Issue Date
15-6월-2020
Publisher
AMER CHEMICAL SOC
Keywords
Stereocomplex polylactide; Stereocomplexation; O/W emulsion blending; Drug infiltration; Nucleating agent
Citation
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v.8, no.23, pp.8752 - 8761
Indexed
SCIE
SCOPUS
Journal Title
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume
8
Number
23
Start Page
8752
End Page
8761
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/55013
DOI
10.1021/acssuschemeng.0c02503
ISSN
2168-0485
Abstract
Biodegradable polymer polylactide (PLA) can form stereocomplex crystals through racemic blending between poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA). This stereocomplexation could lead to substantially improved mechanical and physical strengths for PLA. Various methods for preparing stereocomplex PLA (sc-PLA) have been studied, e.g., solution blending, melt blending, and supercritical fluid (SCF) technology. However, current methods inevitably have various drawbacks including poor efficiency, usability, and low stereocomplexation reaction speeds. Thus, the aim of this study is to develop a novel strategy using oil-in-water (O/W) emulsion blending to overcome the current limitations of stereocomplexation. Our results indicate that the developed strategy can considerably improve the efficiency and accessibility of stereocomplex crystal formation compared to conventional methods such as solution blending and SCF technology. The O/W emulsion blending method exhibits a stereocomplexation efficiency of up to nearly 99%. Additionally, the sc-PLA produced by O/W emulsion blending can act as filler in PLA composites, leading to improvement of their mechanical properties. In addition, a cancer drug such as fluorouracil (5-FU) could be infiltrated into sc-PLA during stereocomplexation induced by O/W emulsion blending. Furthermore, sc-PLA with 5-FU prepared by the novel method could be added for ISN-polymerization in order to give both a nucleating effect and an anticancer effect. It suggests that sc-PLA prepared by our novel method could act as a stable carrier for secondary molecules as well as nucleating agents.
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