Phenotype and molecular signature of CD8(+) T cell subsets in T cell- mediated rejections after kidney transplantation
DC Field | Value | Language |
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dc.contributor.author | Ko, Eun Jeong | - |
dc.contributor.author | Seo, Jung-Woo | - |
dc.contributor.author | Kim, Kyoung Woon | - |
dc.contributor.author | Kim, Bo-Mi | - |
dc.contributor.author | Cho, Jang-Hee | - |
dc.contributor.author | Kim, Chan-Duck | - |
dc.contributor.author | Seok, Junhee | - |
dc.contributor.author | Yang, Chul Woo | - |
dc.contributor.author | Lee, Sang-Ho | - |
dc.contributor.author | Chung, Byung Ha | - |
dc.date.accessioned | 2021-08-30T21:21:53Z | - |
dc.date.available | 2021-08-30T21:21:53Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-06-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55022 | - |
dc.description.abstract | We investigated the phenotype and molecular signatures of CD8(+)T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR). We included 121 KTRs and divided them into three groups according to the pathologic or clinical diagnosis: Normal biopsy control (NC)(n= 32), TCMR (n= 50), and long-term graft survival (LTGS)(n= 39). We used flowcytometry and microarray to analyze the phenotype and molecular signatures of CD8(+)T cell subsets using peripheral blood from those patients and analyzed significant gene expressions according to CD8(+)T cell subsets. We investigated whether the analysis of CD8(+)T cell subsets is useful for predicting the development of TCMR. CCR7(+)CD8(+)T cells significantly decreased, but CD28(null)CD57(+)CD8(+)T cells and CCR7(-)CD45RA(+)CD8(+)T cells showed an increase in the TCMR group compared to other groups (p<0.05 for each); hence CCR7(+)CD8(+)T cells showed significant negative correlations to both effector CD8(+)T cells. We identified genes significantly associated with the change of CCR7(+)CD8(+)T, CCR7(-)CD45RA(+)CD8(+)T, and CD28(null)CD57(+)CD8(+)T cells in anex vivostudy and found that most of them were included in the significant genes onin vitroCCR7(+)CD8(+)T cells. Finally, the decrease of CCR7(+)CD8(+)T cells relative to CD28(null)CD57(+)T or CCR7(-)CD45RA(+)CD8(+)T cells can predict TCMR significantly in the whole clinical cohort. In conclusion, phenotype and molecular signature of CD8(+)T subsets showed a significant relationship to the development of TCMR; hence monitoring of CD8(+)T cell subsets may be a useful for predicting TCMR in KTRs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | MICROARRAYS | - |
dc.subject | RECIPIENTS | - |
dc.subject | CD28 | - |
dc.title | Phenotype and molecular signature of CD8(+) T cell subsets in T cell- mediated rejections after kidney transplantation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seok, Junhee | - |
dc.identifier.doi | 10.1371/journal.pone.0234323 | - |
dc.identifier.scopusid | 2-s2.0-85086525200 | - |
dc.identifier.wosid | 000542037200027 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.15, no.6 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MICROARRAYS | - |
dc.subject.keywordPlus | RECIPIENTS | - |
dc.subject.keywordPlus | CD28 | - |
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