Mitochondrial Relocation of a Common Synthetic Antibiotic: A Non-genotoxic Approach to Cancer Therapy
DC Field | Value | Language |
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dc.contributor.author | Sunwoo, Kyoung | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Ko, Kyung-Phil | - |
dc.contributor.author | Choi, Miri | - |
dc.contributor.author | Arambula, Jonathan F. | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.contributor.author | Sessler, Jonathan L. | - |
dc.contributor.author | Verwilst, Peter | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-08-30T21:22:59Z | - |
dc.date.available | 2021-08-30T21:22:59Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-06-11 | - |
dc.identifier.issn | 2451-9294 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55028 | - |
dc.description.abstract | Tumor recurrence as a result of therapy-induced nuclear DNA lesions is a major issue in cancer treatment. Currently, only a few examples of potentially non-genotoxic drugs have been reported. Mitochondrial re-localization of ciprofloxacin, one of the most commonly prescribed synthetic antibiotics, is reported here as a new approach. Conjugation of ciprofloxacin to a triphenyl phosphonium group (giving lead Mt-CFX) is used to enhance the concentration of ciprofloxacin in the mitochondria of cancer cells. The localization of Mt-CFX to the mitochondria induces oxidative damage to proteins, mtDNA, and lipids. A large bias in favor of mtDNA damage over nDNA was seen with Mt-CFX, contrary to classic cancer chemotherapeutics. Mt-CFX was found to reduce cancer growth in a xenograft mouse model and proved to be well tolerated. Mitochondrial re-localization of antibiotics could emerge as a useful approach to generating anticancer leads that promote cell death via the selective induction of mitochondrially mediated oxidative damage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | ACUTE MYELOID-LEUKEMIA | - |
dc.subject | REPAIR | - |
dc.title | Mitochondrial Relocation of a Common Synthetic Antibiotic: A Non-genotoxic Approach to Cancer Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, Miae | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.chempr.2020.03.004 | - |
dc.identifier.scopusid | 2-s2.0-85083007577 | - |
dc.identifier.wosid | 000540905600027 | - |
dc.identifier.bibliographicCitation | CHEM, v.6, no.6, pp.1408 - 1419 | - |
dc.relation.isPartOf | CHEM | - |
dc.citation.title | CHEM | - |
dc.citation.volume | 6 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1408 | - |
dc.citation.endPage | 1419 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordAuthor | ciprofloxacin | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | non-genotoxic cancer therapy | - |
dc.subject.keywordAuthor | prodrug | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | SDG3: Good health and well-being | - |
dc.subject.keywordAuthor | targeted therapeutics | - |
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