In Situ Magnetic Control of Macroscale Nanoligand Density Regulates the Adhesion and Differentiation of Stem Cells
DC Field | Value | Language |
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dc.contributor.author | Khatua, Chandra | - |
dc.contributor.author | Min, Sunhong | - |
dc.contributor.author | Jung, Hee Joon | - |
dc.contributor.author | Shin, Jeong Eun | - |
dc.contributor.author | Li, Na | - |
dc.contributor.author | Jun, Indong | - |
dc.contributor.author | Liu, Hui-Wen | - |
dc.contributor.author | Bae, Gunhyu | - |
dc.contributor.author | Choi, Hyojun | - |
dc.contributor.author | Ko, Min Jun | - |
dc.contributor.author | Jeon, Yoo Sang | - |
dc.contributor.author | Kim, Yu Jin | - |
dc.contributor.author | Lee, Joonbum | - |
dc.contributor.author | Ko, Minji | - |
dc.contributor.author | Shim, Gyubo | - |
dc.contributor.author | Shin, Hongchul | - |
dc.contributor.author | Lee, Sangbum | - |
dc.contributor.author | Chung, Seok | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.contributor.author | Dravid, Vinayak P. | - |
dc.contributor.author | Kang, Heemin | - |
dc.date.accessioned | 2021-08-30T21:23:55Z | - |
dc.date.available | 2021-08-30T21:23:55Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-06-10 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55035 | - |
dc.description.abstract | Developing materials with remote controllability of macroscale ligand presentation can mimic extracellular matrix (ECM) remodeling to regulate cellular adhesion in vivo. Herein, we designed charged mobile nanoligands with superparamagnetic nanomaterials amine-functionalized and conjugated with poly-ethylene glycol linker and negatively charged RGD ligand. We coupled negatively a charged nanoligand to a positively charged substrate by optimizing electrostatic interactions to allow reversible planar movement. We demonstrate the imaging of both macroscale and in situ nanoscale nanoligand movement by magnetically attracting charged nanoligand to manipulate macroscale ligand density. We show that in situ magnetic control of attracting charged nanoligand facilitates stem cell adhesion, both in vitro and in vivo, with reversible control. Furthermore, we unravel that in situ magnetic attraction of charged nanoligand stimulates mechanosensing- mediated differentiation of stem cells. This remote controllability of ECM-mimicking reversible ligand variations is promising for regulating diverse reparative cellular processes in vivo. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | GROWTH | - |
dc.subject | MANIPULATION | - |
dc.subject | MOTILITY | - |
dc.subject | IMPACT | - |
dc.subject | MATRIX | - |
dc.subject | ORDER | - |
dc.title | In Situ Magnetic Control of Macroscale Nanoligand Density Regulates the Adhesion and Differentiation of Stem Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Seok | - |
dc.contributor.affiliatedAuthor | Kim, Young Keun | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1021/acs.nanolett.0c00559 | - |
dc.identifier.scopusid | 2-s2.0-85085657253 | - |
dc.identifier.wosid | 000541691200016 | - |
dc.identifier.bibliographicCitation | NANO LETTERS, v.20, no.6, pp.4188 - 4196 | - |
dc.relation.isPartOf | NANO LETTERS | - |
dc.citation.title | NANO LETTERS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 4188 | - |
dc.citation.endPage | 4196 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MANIPULATION | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | ORDER | - |
dc.subject.keywordAuthor | charged nanoligand | - |
dc.subject.keywordAuthor | spatial ligand movement | - |
dc.subject.keywordAuthor | reversible ligand movement | - |
dc.subject.keywordAuthor | cell adhesion | - |
dc.subject.keywordAuthor | stem cell differentiation | - |
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