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Improvement of medication adherence with simplified once-daily immunosuppressive regimen in stable kidney transplant recipients: A prospective cohort study

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dc.contributor.authorOh, Chang-Kwon-
dc.contributor.authorBang, Jun Bae-
dc.contributor.authorKim, Sung-Joo-
dc.contributor.authorHuh, Kyu Ha-
dc.contributor.authorKim, Soo Jin-
dc.contributor.authorJeon, Jin Seok-
dc.contributor.authorHan, Sang Youb-
dc.contributor.authorCho, Hong Rae-
dc.contributor.authorKwon, Young Joo-
dc.contributor.authorLee, Su Hyung-
dc.contributor.authorKim, Yu Seun-
dc.date.accessioned2021-08-30T22:19:17Z-
dc.date.available2021-08-30T22:19:17Z-
dc.date.created2021-06-18-
dc.date.issued2020-06-
dc.identifier.issn1015-9584-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/55497-
dc.description.abstractBackground: Many immunosuppressive drugs are prescribed as twice-daily dosing. A simplified once-daily dosing of immunosuppressive drug regimen may improve medication adherence. We investigated medication adherence of simplified once-daily immunosuppressive regimen consisting of extended-release tacrolimus, sirolimus, and corticosteroids along with the efficacy and safety of this regimen. Methods: This study was a prospective, multicenter, controlled and cohort trial. Stable kidney transplant recipients who had received transplantation at least 3 months before the study enrollment were eligible for the study. Participants were required to fill-out the self-reported immunosuppressant therapy barrier scale (ITBS) questionnaire before and after the conversion. Other clinical laboratory parameters and adverse events were evaluated until 6 months post-conversion. Results: A total of 160 kidney recipients comprised the intention-to-treat population. The mean total ITBS score was 19.5 +/- 14.0 at pre-conversion and 6 months after converting, the mean total ITBS score was 16.6 +/- 13.6 (p < 0.001). Particularly, the ITBS scores of 4 questions related to the frequency of medication dosing were significantly different between pre-conversion and post-conversion. Only 1 patient (0.62%) was diagnosed as biopsy-confirmed acute rejection in the study period. There was no significant change in the mean estimated glomerular filtration rate after the conversion. Overall 95 patients (59.4%) had an adverse event and 28 patients (17.5%) had a serious adverse event. No graft loss and 1 death were reported. Conclusion: Medication adherence after the conversion to the once-daily immunosuppressive regimen was significantly improved with no additional risks of efficacy failure or adverse events. (C) 2019 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherELSEVIER SINGAPORE PTE LTD-
dc.subjectTWICE-DAILY TACROLIMUS-
dc.subjectRENAL-TRANSPLANTATION-
dc.subjectCALCINEURIN INHIBITORS-
dc.subjectREDUCED-EXPOSURE-
dc.subjectPROGRAF-
dc.subjectFORMULATION-
dc.subjectADVAGRAF-
dc.subjectNONCOMPLIANCE-
dc.subjectREJECTION-
dc.subjectSIROLIMUS-
dc.titleImprovement of medication adherence with simplified once-daily immunosuppressive regimen in stable kidney transplant recipients: A prospective cohort study-
dc.typeArticle-
dc.contributor.affiliatedAuthorKwon, Young Joo-
dc.identifier.doi10.1016/j.asjsur.2019.07.011-
dc.identifier.scopusid2-s2.0-85071382227-
dc.identifier.wosid000533537500003-
dc.identifier.bibliographicCitationASIAN JOURNAL OF SURGERY, v.43, no.6, pp.660 - 667-
dc.relation.isPartOfASIAN JOURNAL OF SURGERY-
dc.citation.titleASIAN JOURNAL OF SURGERY-
dc.citation.volume43-
dc.citation.number6-
dc.citation.startPage660-
dc.citation.endPage667-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaSurgery-
dc.relation.journalWebOfScienceCategorySurgery-
dc.subject.keywordPlusTWICE-DAILY TACROLIMUS-
dc.subject.keywordPlusRENAL-TRANSPLANTATION-
dc.subject.keywordPlusCALCINEURIN INHIBITORS-
dc.subject.keywordPlusREDUCED-EXPOSURE-
dc.subject.keywordPlusPROGRAF-
dc.subject.keywordPlusFORMULATION-
dc.subject.keywordPlusADVAGRAF-
dc.subject.keywordPlusNONCOMPLIANCE-
dc.subject.keywordPlusREJECTION-
dc.subject.keywordPlusSIROLIMUS-
dc.subject.keywordAuthorMedication adherence-
dc.subject.keywordAuthorKidney transplantation-
dc.subject.keywordAuthorImmunosuppression-
dc.subject.keywordAuthorTacrolimus-
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