Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to Extended-Spectrum-beta-Lactamase-Producing Burkholderia thailandensis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yi, Hyojeong | - |
dc.contributor.author | Park, Jongwook | - |
dc.contributor.author | Cho, Kwang-Hwi | - |
dc.contributor.author | Kim, Heenam Stanley | - |
dc.date.accessioned | 2021-08-30T22:19:27Z | - |
dc.date.available | 2021-08-30T22:19:27Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55498 | - |
dc.description.abstract | Highly conserved PenI-type class A beta-lactamase in pathogenic members of Burkholderia species can evolve to extended-spectrum beta-lactamase (ESBL), which exhibits hydrolytic activity toward third-generation cephalosporins, while losing its activity toward the original penicillin substrates. We describe three single-amino-acid-substitution mutations in the ArgS arginine-tRNA synthetase that confer extra antibiotic tolerance protection to ESBL-producing Burkholderia thailandensis. This pathway can be exploited to evade antibiotic tolerance induction in developing therapeutic measures against Burkholderia species, targeting their essential aminoacyl-tRNA synthetases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.title | Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to Extended-Spectrum-beta-Lactamase-Producing Burkholderia thailandensis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Heenam Stanley | - |
dc.identifier.doi | 10.1128/AAC.02252-19 | - |
dc.identifier.scopusid | 2-s2.0-85085263465 | - |
dc.identifier.wosid | 000535946300046 | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.64, no.6 | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.citation.title | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordAuthor | arginine-tRNA synthetase | - |
dc.subject.keywordAuthor | ArgS | - |
dc.subject.keywordAuthor | antibiotic tolerance | - |
dc.subject.keywordAuthor | stringent response | - |
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