Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Shin | - |
dc.contributor.author | Jung, Sung-Hoon | - |
dc.contributor.author | Do, Young Rok | - |
dc.contributor.author | Kim, Dae Sik | - |
dc.contributor.author | Lee, Ji Hyun | - |
dc.contributor.author | Park, Han-Seung | - |
dc.contributor.author | Moon, Joon Ho | - |
dc.contributor.author | Yi, Jun Ho | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Yhim, Ho-Young | - |
dc.contributor.author | Choi, Yunsuk | - |
dc.contributor.author | Mun, Yeung-Chul | - |
dc.contributor.author | Lee, Won-Sik | - |
dc.contributor.author | Lee, Seok | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.date.accessioned | 2021-08-30T22:19:55Z | - |
dc.date.available | 2021-08-30T22:19:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55502 | - |
dc.description.abstract | Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) with optimal conditioning has helped better long-term survival in acute lymphoblastic leukemia (ALL). This study investigated the efficacy and safety of reduced-intensity conditioning (RIC) with busulfan and fludarabine in adult ALL patients unfit for myeloablation. Materials and Methods: Records of 78 patients who underwent HSCT with RIC consisting of 3.2 mg/kg/day of busulfan for 2 or 3 days and 30 mg/m(2)/day of fludarabine for 5 or 6 days were analyzed. Results: The median age at diagnosis was 49 years. Over a median follow-up of 22 months, 2-year estimates of relapse-free survival (RFS) and overall survival were 57.4% and 68.7%, respectively. Multivariate analysis showed a trend of improved RFS in patients with chronic graft-versus-host disease (GVHD) (hazard ratio, 0.53; 95% confidence interval, 0.26-1.08; p=0.080). The cumulative incidences of relapse and non-relapse mortality were 42.9% and 19.6%, respectively and one case of central nervous system relapse was noted. No hepatic veno-occlusive disease was reported. Grade II-IV acute GVHD and any grade chronic GVHD occurred in 21.1% and 41.7%, respectively. Conclusion: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | DISEASE | - |
dc.subject | ADULTS | - |
dc.subject | RISK | - |
dc.title | Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sik | - |
dc.contributor.affiliatedAuthor | Park, Yong | - |
dc.identifier.doi | 10.3349/ymj.2020.61.6.452 | - |
dc.identifier.wosid | 000537346300002 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.61, no.6, pp.452 - 459 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 61 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 452 | - |
dc.citation.endPage | 459 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002587980 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Fludarabine | - |
dc.subject.keywordAuthor | busulfan | - |
dc.subject.keywordAuthor | lymphoblastic leukemia | - |
dc.subject.keywordAuthor | stem cell transplantation | - |
dc.subject.keywordAuthor | transplantation conditioning | - |
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