Diabetes mellitus increases mortality in acute pyelonephritis patients: a population study based on the National Health Insurance Claim Data of South Korea for 2010-2014
- Authors
- Kim, Bongyoung; Myung, Rangmi; Kim, Gheun-Ho; Lee, Myoung-Jae; Kim, Jieun; Pai, Hyunjoo
- Issue Date
- 6월-2020
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Diabetes; Pyelonephritis; Mortality
- Citation
- INFECTION, v.48, no.3, pp.435 - 443
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFECTION
- Volume
- 48
- Number
- 3
- Start Page
- 435
- End Page
- 443
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55547
- DOI
- 10.1007/s15010-020-01419-2
- ISSN
- 0300-8126
- Abstract
- Objective Diabetes mellitus has been suspected to increase mortality in acute pyelonephritis (APN) patients and the goal of this study is to verify this suspicion with a large data set based on almost the entire population of South Korea. Methods A nationwide cohort study was conducted using a South Korean Health Insurance Review and Assessment Service claim database. We collected demographic and clinical information including comorbidities of patients with APN as the primary discharge diagnosis during 2010-2014. Then we compared the in-hospital mortality and recurrence of APN across the diabetes and non-diabetes groups. Results Among 845,656 APN patients, 12.4% had diabetes mellitus. The median age was 65 in the diabetes group, which was much higher than 47 in the non-diabetes group; the female proportion was 91-92% in both groups. The in-hospital mortality rate was higher in the diabetes group (2.6/1000 events in the diabetes group vs. 0.3/1000 in the non-diabetes group, P < 0.001). When covariates (age, sex, and the modified Charlson comorbidity index) were controlled with panel logistic regression, diabetes was still associated with a higher in-hospital mortality in APN patients (OR 2.66, 95% CI 2.19-3.23). The increasing effect of diabetes on in-hospital mortality of APN patients varied greatly with age: the effect was large for age 15-49 (OR 15.06, 95% CI 5.27-43.05), slightly smaller for age 50-64 (OR 12.17, 95% CI 5.71-25.92), and much smaller for age >= 65 (OR 2.10, 95% CI 1.72-1.92). Conclusions Our data indicate that the mortality of APN is higher in the patients with diabetes and this effect becomes stronger for young patients.
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Collections - College of Political Science & Economics > Department of Economics > 1. Journal Articles
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