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Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

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dc.contributor.authorAn, Lijun-
dc.contributor.authorMa, Jun-
dc.contributor.authorYang, Xueyuan-
dc.contributor.authorLiang, Yue-
dc.contributor.authorWang, Huimei-
dc.contributor.authorTuerhong, Muhetaer-
dc.contributor.authorLall, Namrita-
dc.contributor.authorAbudukeremu, Munira-
dc.contributor.authorZhang, Yi-
dc.contributor.authorLee, Dongho-
dc.contributor.authorXu, Jing-
dc.contributor.authorWu, Xiaohui-
dc.contributor.authorGuo, Yuanqiang-
dc.date.accessioned2021-08-31T01:08:04Z-
dc.date.available2021-08-31T01:08:04Z-
dc.date.created2021-06-19-
dc.date.issued2020-05-
dc.identifier.issn0045-2068-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/56097-
dc.description.abstractCaseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectCYTOTOXIC CLERODANE DITERPENOIDS-
dc.subjectLEAVES-
dc.subjectSYLVESTRIS-
dc.subjectTRITERPENOIDS-
dc.subjectDERIVATIVES-
dc.subjectINHIBITOR-
dc.subjectGLYCOSIDE-
dc.subjectTWIGS-
dc.subjectBARK-
dc.titleCaseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1016/j.bioorg.2020.103758-
dc.identifier.scopusid2-s2.0-85082433633-
dc.identifier.wosid000526784800007-
dc.identifier.bibliographicCitationBIOORGANIC CHEMISTRY, v.98-
dc.relation.isPartOfBIOORGANIC CHEMISTRY-
dc.citation.titleBIOORGANIC CHEMISTRY-
dc.citation.volume98-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusCYTOTOXIC CLERODANE DITERPENOIDS-
dc.subject.keywordPlusLEAVES-
dc.subject.keywordPlusSYLVESTRIS-
dc.subject.keywordPlusTRITERPENOIDS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusINHIBITOR-
dc.subject.keywordPlusGLYCOSIDE-
dc.subject.keywordPlusTWIGS-
dc.subject.keywordPlusBARK-
dc.subject.keywordAuthorHomotriterpenoid-
dc.subject.keywordAuthorAnti-inflammation-
dc.subject.keywordAuthorZebrafish model-
dc.subject.keywordAuthorMolecular docking-
dc.subject.keywordAuthorCasearia kurzii-
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