Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, Feng-Yan | - |
dc.contributor.author | Lim, Byung-Gun | - |
dc.contributor.author | Wen, Wen | - |
dc.contributor.author | Zhang, Yu | - |
dc.contributor.author | Cao, Bo | - |
dc.contributor.author | Si, Yue-Guang | - |
dc.contributor.author | Ma, Li-Qing | - |
dc.contributor.author | Deng, Meng | - |
dc.contributor.author | Kim, Yang In | - |
dc.contributor.author | Kim, Young-Beom | - |
dc.contributor.author | Wang, Ying-Wei | - |
dc.date.accessioned | 2021-08-31T01:08:36Z | - |
dc.date.available | 2021-08-31T01:08:36Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 1673-7067 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/56101 | - |
dc.description.abstract | In the current study, we sought to investigate whether T-type Ca2+ channels (TCCs) in the brain are involved in generating post-anesthetic hyperexcitatory behaviors (PAHBs). We found that younger rat pups (postnatal days 9-11) had a higher incidence of PAHBs and higher PAHB scores than older pups (postnatal days 16-18) during emergence from sevoflurane anesthesia. The power spectrum of the theta oscillations (4 Hz-8 Hz) in the prefrontal cortex was significantly enhanced in younger pups when PAHBs occurred, while there were no significant changes in older pups. Both the power of theta oscillations and the level of PAHBs were significantly reduced by the administration of TCC inhibitors. Moreover, the sensitivity of TCCs in the medial dorsal thalamic nucleus to sevoflurane was found to increase with age by investigating the kinetic properties of TCCs in vitro. TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane (1%). These data suggest that (1) TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes; (2) the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats; and (3) the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | NEURONS | - |
dc.subject | DELIRIUM | - |
dc.subject | ISOFLURANE | - |
dc.subject | PREVENTION | - |
dc.subject | AGITATION | - |
dc.subject | GABA | - |
dc.title | Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Byung-Gun | - |
dc.contributor.affiliatedAuthor | Kim, Yang In | - |
dc.contributor.affiliatedAuthor | Kim, Young-Beom | - |
dc.identifier.doi | 10.1007/s12264-019-00461-x | - |
dc.identifier.scopusid | 2-s2.0-85078612583 | - |
dc.identifier.wosid | 000507779800001 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE BULLETIN, v.36, no.5, pp.519 - 529 | - |
dc.relation.isPartOf | NEUROSCIENCE BULLETIN | - |
dc.citation.title | NEUROSCIENCE BULLETIN | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 519 | - |
dc.citation.endPage | 529 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | DELIRIUM | - |
dc.subject.keywordPlus | ISOFLURANE | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | AGITATION | - |
dc.subject.keywordPlus | GABA | - |
dc.subject.keywordAuthor | Emergence agitation | - |
dc.subject.keywordAuthor | Neonatal rat | - |
dc.subject.keywordAuthor | General anesthesia | - |
dc.subject.keywordAuthor | Sevoflurane | - |
dc.subject.keywordAuthor | T-type calcium channel | - |
dc.subject.keywordAuthor | Theta wave | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.