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Fucosterol Suppresses the Progression of Human Ovarian Cancer by Inducing Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Authors
Bae, HyocheolLee, Jin-YoungSong, GwonhwaLim, Whasun
Issue Date
5월-2020
Publisher
MDPI
Keywords
fucosterol; ovarian cancer; mitochondria; ER; viability
Citation
MARINE DRUGS, v.18, no.5
Indexed
SCIE
SCOPUS
Journal Title
MARINE DRUGS
Volume
18
Number
5
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/56144
DOI
10.3390/md18050261
ISSN
1660-3397
Abstract
Ovarian cancer is difficult to diagnose early and has high rates of relapse and mortality. Therefore, the treatment of ovarian cancer needs to be improved. Recently, several studies have been conducted in an attempt to develop anticancer drugs from naturally derived ingredients. Compared to traditional chemotherapy, natural compounds can overcome drug resistance with lower side effects. Fucosterol, a phytosterol present in brown algae, reportedly possesses many bioactive effects, including anticancer properties. However, the anticancer effects of fucosterol in ovarian cancer remain unexplored. Therefore, we investigated the effects of fucosterol on progression in human ovarian cancer cells. Fucosterol inhibited cell proliferation and cell-cycle progression in ovarian cancer cells. Additionally, fucosterol regulated the proliferation-related signaling pathways, the production of reactive oxygen species, mitochondrial function, endoplasmic reticulum stress, angiogenesis, and calcium homeostasis. Moreover, it decreased tumor formation in a zebrafish xenograft model. These results indicate that fucosterol could be used as a potential therapeutic agent in ovarian cancer.
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