Elevated Cerebrospinal Fluid and Plasma N-Cadherin in Alzheimer Disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Ji-Young | - |
dc.contributor.author | Cho, Sun-Jung | - |
dc.contributor.author | Park, Jung Hyun | - |
dc.contributor.author | Yun, Sang-Moon | - |
dc.contributor.author | Jo, Chulman | - |
dc.contributor.author | Kim, Eun-Joo | - |
dc.contributor.author | Huh, Gi Yeong | - |
dc.contributor.author | Park, Moon Ho | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Koh, Young Ho | - |
dc.date.accessioned | 2021-08-31T01:37:12Z | - |
dc.date.available | 2021-08-31T01:37:12Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0022-3069 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/56178 | - |
dc.description.abstract | N-cadherin is a synaptic adhesion molecule stabilizing synaptic cell structure and function. Cleavage of N-cadherin by gamma-secretase produces a C-terminal fragment, which is increased in the brains of Alzheimer disease (AD) patients. Here, we investigated the relationship between fluid N-cadherin levels and AD pathology. We first showed that the cleaved levels of N-cadherin were increased in homogenates of postmortem brain from AD patients compared with that in non-AD patients. We found that cleaved N-cadherin levels in the cerebrospinal fluid were increased in AD dementia compared with that in healthy control. ELISA results revealed that plasma levels of N-cadherin in 76 patients with AD were higher than those in 133 healthy control subjects. The N-cadherin levels in the brains of an AD mouse model, APP Swedish/PS1delE9 Tg (APP Tg) were reduced compared with that in control. The N-terminal fragment of N-cadherin produced by cleavage at a plasma membrane was detected extravascularly, accumulated in senile plaques in the cortex of an APP Tg mouse. In addition, N-cadherin plasma levels were increased in APP Tg mice. Collectively, our study suggests that alteration of N-cadherin levels might be associated with AD pathology. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | BETA-CATENIN | - |
dc.subject | HOMOCYSTEINE | - |
dc.subject | EXPRESSION | - |
dc.subject | DEMENTIA | - |
dc.subject | LOCALIZATION | - |
dc.subject | COOPERATION | - |
dc.subject | JUNCTIONS | - |
dc.subject | CLEAVAGE | - |
dc.subject | ADHESION | - |
dc.subject | ADAM10 | - |
dc.title | Elevated Cerebrospinal Fluid and Plasma N-Cadherin in Alzheimer Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Moon Ho | - |
dc.contributor.affiliatedAuthor | Han, Changsu | - |
dc.identifier.doi | 10.1093/jnen/nlaa019 | - |
dc.identifier.scopusid | 2-s2.0-85085345773 | - |
dc.identifier.wosid | 000537421300003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, v.79, no.5, pp.484 - 492 | - |
dc.relation.isPartOf | JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | - |
dc.citation.title | JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | - |
dc.citation.volume | 79 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 484 | - |
dc.citation.endPage | 492 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | HOMOCYSTEINE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | COOPERATION | - |
dc.subject.keywordPlus | JUNCTIONS | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | ADAM10 | - |
dc.subject.keywordAuthor | Alzheimer disease | - |
dc.subject.keywordAuthor | Brain | - |
dc.subject.keywordAuthor | Cerebrospinal fluid | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | N-cadherin | - |
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