Dynamic Programming of a DNA Walker Controlled by Protons
- Authors
- Yao, Dongbao; Bhadra, Sanchita; Erhu, Xiong; Liang, Haojun; Ellington, Andrew D.; Jung, Cheulhee
- Issue Date
- 28-4월-2020
- Publisher
- AMER CHEMICAL SOC
- Keywords
- catalytic hairpin assembly; dynamic control; four-legged DNA walker; microparticle; pH-responsive triplex DNA
- Citation
- ACS NANO, v.14, no.4, pp.4007 - 4013
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS NANO
- Volume
- 14
- Number
- 4
- Start Page
- 4007
- End Page
- 4013
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56268
- DOI
- 10.1021/acsnano.9b08166
- ISSN
- 1936-0851
- Abstract
- We have now constructed a four-legged DNA walker based on toehold exchange reactions whose movement is controlled by alternating pH changes. A well-characterized, pH-responsive CG-C+ triplex DNA was embedded into a tetrameric catalytic hairpin assembly (CHA) walker. The proton-controlled walker could autonomously move on otherwise unprogrammed micro-particles surface, and the walking rate and steps of walking were efficiently controlled by pH. The starting and stopping of the walker, and its association and dissociation from the micro-particles, could also be dynamically controlled by pH. The simple, programmable, and robust nature of this proton-controlled walker now provides the impetus for the development of a wide variety of more practical nanomachines.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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