Anti-inflammatory Metabolites from Chaetomium nigricolor
- Authors
- Kim, Min Jee; Kim, Dong-Cheol; Kwon, Jaeyoung; Ryu, Seung Mok; Kwon, Haeun; Guo, Yuanqiang; Hong, Seung-Beom; Kim, Youn-Chul; Oh, Hyuncheol; Lee, Dongho
- Issue Date
- 24-4월-2020
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.83, no.4, pp.881 - 887
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 83
- Number
- 4
- Start Page
- 881
- End Page
- 887
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56280
- DOI
- 10.1021/acs.jnatprod.9b00560
- ISSN
- 0163-3864
- Abstract
- Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-gamma-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E-2, interleukin (IL)-1 beta, tumor necrosis factor-alpha, IL-6, and IL-12.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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