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A microfluidic gradient device for drug screening with human iPSC-derived motoneurons

Authors
Mo, Sung JoonLee, Ju-HyunKye, Hyeon GiLee, Jong MinKim, Eun-JoongGeum, DonghoSun, WoongChung, Bong Geun
Issue Date
21-4월-2020
Publisher
ROYAL SOC CHEMISTRY
Citation
ANALYST, v.145, no.8, pp.3081 - 3089
Indexed
SCIE
SCOPUS
Journal Title
ANALYST
Volume
145
Number
8
Start Page
3081
End Page
3089
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/56291
DOI
10.1039/c9an02384d
ISSN
0003-2654
Abstract
We developed a microfluidic gradient device to utilize as a drug screening system with human induced pluripotent stem cell (hiPSC)-derived motoneurons. The microfluidic channel was asymmetrically designed to generate the concentration gradients and a micropillar array was used to trap and culture the motoneuron spheroids containing motoneurons for 9 days. We optimized the concentration gradients in the microfluidic device using a computational fluid dynamics (CFD) model. We also observed that the motoneuron spheroid-derived neurite network was generated in response to the concentration gradients of riluzole in the microfluidic device. Therefore, this microfluidic gradient device could be useful for screening of various drugs for neurological disease applications.
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