Serum biomarkers from cell-based assays for AhRL and MIS strongly predicted the future development of diabetes in a large community-based prospective study in Korea
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Wook Ha | - |
dc.contributor.author | Kang, Young Cheol | - |
dc.contributor.author | Kang, Sora | - |
dc.contributor.author | Im, Suyeol | - |
dc.contributor.author | Park, Sol | - |
dc.contributor.author | Kim, Jin Taek | - |
dc.contributor.author | Lee, Minhyeok | - |
dc.contributor.author | Seok, Junhee | - |
dc.contributor.author | Oh, Man-Suk | - |
dc.contributor.author | Choi, Hoon Sung | - |
dc.contributor.author | Pak, Youngmi Kim | - |
dc.date.accessioned | 2021-08-31T02:49:14Z | - |
dc.date.available | 2021-08-31T02:49:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-04-14 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/56624 | - |
dc.description.abstract | Exposure to environment-polluting chemicals (EPC) is associated with the development of diabetes. Many EPCs exert toxic effects via aryl hydrocarbon receptor (AhR) and/or mitochondrial inhibition. Here we investigated if the levels of human exposure to a mixture of EPC and/or mitochondrial inhibitors could predict the development of diabetes in a prospective study, the Korean Genome and Epidemiological Study (KoGES). We analysed AhR ligands (AhRL) and mitochondria-inhibiting substances (MIS) in serum samples (n=1,537), collected during the 2008 Ansung KoGES survey with a 4-year-follow-up. Serum AhRL, determined by the AhR-dependent luciferase reporter assay, represents the contamination level of AhR ligand mixture in serum. Serum levels of MIS, analysed indirectly by MIS-ATP or MIS-ROS, are the serum MIS-induced mitochondria inhibiting effects on ATP content or reactive oxygen species (ROS) production in the cultured cells. Among 919 normal subjects at baseline, 7.1% developed impaired glucose tolerance (IGT) and 1.6% diabetes after 4 years. At the baseline, diabetic and IGT sera displayed higher AhRL and MIS than normal sera, which correlated with indices of insulin resistance. When the subjects were classified according to ROC cut-off values, fully adjusted relative risks of diabetes development within 4 years were 7.60 (95% CI, 4.23-13.64), 4.27 (95% CI, 2.38-7.64), and 21.11 (95% CI, 8.46-52.67) for AhRL >= 2.70 pM, MIS-ATP <= 88.1%, and both, respectively. Gender analysis revealed that male subjects with AhRL >= 2.70 pM or MIS-ATP <= 88.1% showed higher risk than female subjects. High serum levels of AhRL and/or MIS strongly predict the future development of diabetes, suggesting that the accumulation of AhR ligands and/or mitochondrial inhibitors in body may play an important role in the pathogenesis of diabetes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ARYL-HYDROCARBON RECEPTOR | - |
dc.subject | PERSISTENT ORGANIC POLLUTANTS | - |
dc.subject | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject | PANCREATIC-ISLETS | - |
dc.subject | WIDE ASSOCIATION | - |
dc.subject | EXPOSURE | - |
dc.subject | HEALTH | - |
dc.subject | METABOLISM | - |
dc.subject | ACTIVATION | - |
dc.subject | CHEMICALS | - |
dc.title | Serum biomarkers from cell-based assays for AhRL and MIS strongly predicted the future development of diabetes in a large community-based prospective study in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Minhyeok | - |
dc.contributor.affiliatedAuthor | Seok, Junhee | - |
dc.identifier.doi | 10.1038/s41598-020-62550-6 | - |
dc.identifier.scopusid | 2-s2.0-85083545009 | - |
dc.identifier.wosid | 000562162800017 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ARYL-HYDROCARBON RECEPTOR | - |
dc.subject.keywordPlus | PERSISTENT ORGANIC POLLUTANTS | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject.keywordPlus | PANCREATIC-ISLETS | - |
dc.subject.keywordPlus | WIDE ASSOCIATION | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CHEMICALS | - |
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