Dietary intake ofLycium ruthenicumMurray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis
DC Field | Value | Language |
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dc.contributor.author | Zong, Shuai | - |
dc.contributor.author | Yang, Liu | - |
dc.contributor.author | Park, Hyun Jin | - |
dc.contributor.author | Li, Jinglei | - |
dc.date.accessioned | 2021-08-31T04:36:55Z | - |
dc.date.available | 2021-08-31T04:36:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-04-01 | - |
dc.identifier.issn | 2042-650X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/56691 | - |
dc.description.abstract | In this study, phytochemical compositions ofLycium ruthenicumMurray ethanol extract (LRE) were analyzed by LC-ESI-MS/MS and the protective effect of LRE on inflammatory bowel disease (IBD) was evaluated in a dextran sulfate sodium (DSS) induced experimental colitis mice model. The results showed that a total of 129 compounds were tentatively identified, including phenols/phenolic acids, flavonoids and others. LRE supplementation significantly reduced DSS-induced body weight loss, disease activity index increase, colon length shortening and colonic pathological damage. LRE inhibited intestinal inflammation by regulating nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) pathways, restored intestinal immune homeostasis by regulating immune cell infiltration and T lymphocyte subsets, and suppressed (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation. Moreover, the LRE profoundly ameliorated aberrant oxidative stress and restored the intestinal barrier integrity of colitis. Together, LRE supplementation might provide a new dietary strategy for preventing and ameliorating IBD as a functional food. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | LYCIUM-RUTHENICUM | - |
dc.subject | PHENOLIC-COMPOUNDS | - |
dc.subject | INTESTINAL INFLAMMATION | - |
dc.subject | POLYSACCHARIDE | - |
dc.subject | ACTIVATION | - |
dc.subject | MICE | - |
dc.subject | CYCLOPHOSPHAMIDE | - |
dc.subject | ANTHOCYANIN | - |
dc.subject | MURRAY | - |
dc.subject | MODEL | - |
dc.title | Dietary intake ofLycium ruthenicumMurray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hyun Jin | - |
dc.identifier.doi | 10.1039/d0fo00172d | - |
dc.identifier.scopusid | 2-s2.0-85084189957 | - |
dc.identifier.wosid | 000556523100007 | - |
dc.identifier.bibliographicCitation | FOOD & FUNCTION, v.11, no.4, pp.2924 - 2937 | - |
dc.relation.isPartOf | FOOD & FUNCTION | - |
dc.citation.title | FOOD & FUNCTION | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2924 | - |
dc.citation.endPage | 2937 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | LYCIUM-RUTHENICUM | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | INTESTINAL INFLAMMATION | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | CYCLOPHOSPHAMIDE | - |
dc.subject.keywordPlus | ANTHOCYANIN | - |
dc.subject.keywordPlus | MURRAY | - |
dc.subject.keywordPlus | MODEL | - |
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