A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMETTM Plus Platform
DC Field | Value | Language |
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dc.contributor.author | Gim, Jeong-An | - |
dc.contributor.author | Kwon, Yonghan | - |
dc.contributor.author | Lee, Hyun A. | - |
dc.contributor.author | Lee, Kyeong-Ryoon | - |
dc.contributor.author | Kim, Soohyun | - |
dc.contributor.author | Choi, Yoonjung | - |
dc.contributor.author | Kim, Yu Kyong | - |
dc.contributor.author | Lee, Howard | - |
dc.date.accessioned | 2021-08-31T04:56:35Z | - |
dc.date.available | 2021-08-31T04:56:35Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/56841 | - |
dc.description.abstract | Tacrolimus is an immunosuppressive drug with a narrow therapeutic index and larger interindividual variability. We identified genetic variants to predict tacrolimus exposure in healthy Korean males using machine learning algorithms such as decision tree, random forest, and least absolute shrinkage and selection operator (LASSO) regression. rs776746 (CYP3A5) and rs1137115 (CYP2A6) are single nucleotide polymorphisms (SNPs) that can affect exposure to tacrolimus. A decision tree, when coupled with random forest analysis, is an efficient tool for predicting the exposure to tacrolimus based on genotype. These tools are helpful to determine an individualized dose of tacrolimus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | DOSE REQUIREMENTS | - |
dc.subject | ACUTE REJECTION | - |
dc.subject | CYP3A5 | - |
dc.subject | PHARMACOGENETICS | - |
dc.subject | CLASSIFICATION | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | DETERMINANTS | - |
dc.subject | ASSOCIATION | - |
dc.subject | VARIANTS | - |
dc.title | A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMETTM Plus Platform | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gim, Jeong-An | - |
dc.identifier.doi | 10.3390/ijms21072517 | - |
dc.identifier.scopusid | 2-s2.0-85083022610 | - |
dc.identifier.wosid | 000535574200259 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.7 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | DOSE REQUIREMENTS | - |
dc.subject.keywordPlus | ACUTE REJECTION | - |
dc.subject.keywordPlus | CYP3A5 | - |
dc.subject.keywordPlus | PHARMACOGENETICS | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | DETERMINANTS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordAuthor | decision tree | - |
dc.subject.keywordAuthor | random forest | - |
dc.subject.keywordAuthor | machine learning | - |
dc.subject.keywordAuthor | tacrolimus | - |
dc.subject.keywordAuthor | genotype | - |
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