Multifunctional imaging of amyloid-beta peptides with a new gadolinium-based contrast agent in Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Garam | - |
dc.contributor.author | Kim, Hee-Kyung | - |
dc.contributor.author | Baek, Ah Rum | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Kim, Minsup | - |
dc.contributor.author | Cho, Art E. | - |
dc.contributor.author | Lee, Gang-Ho | - |
dc.contributor.author | Jung, Hoesu | - |
dc.contributor.author | Yang, Ji-ung | - |
dc.contributor.author | Lee, Taekwan | - |
dc.contributor.author | Chang, Yongmin | - |
dc.date.accessioned | 2021-08-31T06:18:31Z | - |
dc.date.available | 2021-08-31T06:18:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-03-25 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57223 | - |
dc.description.abstract | Multifunctional imaging of the deposition of amyloid-beta (A beta) aggregates in the brain is of great importance in diagnosing Alzheimer's disease. Herein, we report a multifunctional A beta-targeting small-molecular-weight gadolinium (Gd)-based contrast agent (CA), Gd-DO3A-Chal (a new Gd-chelate conjugated with chalcone), that showed 8 times higher binding affinity to A beta aggregates than a previously reported Gd-chelate conjugated with Pittsburgh compound B. Gd-DO3A-Chat showed multimodal imaging capability. As a new fluorescence imaging probe, Gd-DO3A-Chal showed a good match with immunostained images using 6E10 monoclonal antibodies for the detection of A beta aggregates in 5XFAD transgenic mouse brain sections. For in vivo magnetic resonance (MR) imaging without blood-brain barrier disruption, longitudinal relaxation time (T-1)-weighted MR images after intravenous administration of Gd-DO3A-Chal showed signal enhancement of the A beta distribution in living 5XFAD transgenic mouse brain. Therefore, in vivo MR images for A beta detection in addition to fluorescent optical images of A beta aggregates with high specificity and sensitivity using this new multifunctional A beta-targeting CA were successfully demonstrated. (C) 2019 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | PLAQUES | - |
dc.subject | PROBES | - |
dc.subject | BINDING | - |
dc.subject | COMPLEXES | - |
dc.subject | INSIGHTS | - |
dc.subject | DESIGN | - |
dc.title | Multifunctional imaging of amyloid-beta peptides with a new gadolinium-based contrast agent in Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Art E. | - |
dc.identifier.doi | 10.1016/j.jiec.2019.11.031 | - |
dc.identifier.scopusid | 2-s2.0-85076240294 | - |
dc.identifier.wosid | 000514214400024 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.83, pp.214 - 223 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 83 | - |
dc.citation.startPage | 214 | - |
dc.citation.endPage | 223 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002568656 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordAuthor | Gadolinium complex | - |
dc.subject.keywordAuthor | Magnetic resonance contrast agent | - |
dc.subject.keywordAuthor | Chalcone | - |
dc.subject.keywordAuthor | Derivative | - |
dc.subject.keywordAuthor | Multifunctional imaging | - |
dc.subject.keywordAuthor | Amyloid imaging | - |
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