Unimolecular Photodynamic O-2-Economizer To Overcome Hypoxia Resistance in Phototherapeutics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Mingle | - |
dc.contributor.author | Shao, Yujie | - |
dc.contributor.author | Kim, Ji Hyeon | - |
dc.contributor.author | Pu, Zhongji | - |
dc.contributor.author | Zhao, Xueze | - |
dc.contributor.author | Huang, Haiqiao | - |
dc.contributor.author | Xiong, Tao | - |
dc.contributor.author | Kang, Yao | - |
dc.contributor.author | Li, Guangzhe | - |
dc.contributor.author | Shao, Kun | - |
dc.contributor.author | Fan, Jiangli | - |
dc.contributor.author | Foley, James W. | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Peng, Xiaojun | - |
dc.date.accessioned | 2021-08-31T06:22:41Z | - |
dc.date.available | 2021-08-31T06:22:41Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-03-18 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57252 | - |
dc.description.abstract | Tumor hypoxia has proven to be the major bottleneck of photodynamic therapy (PDT) to clinical transformation. Different from traditional O-2 delivery approaches, here we describe an innovative binary photodynamic O-2-economizer (PDOE) tactic to reverse hypoxia-driven resistance by designing a superoxide radical (O-2(center dot-)) generator targeting mitochondria respiration, termed SORgenTAM. This PDOE system is able to block intracellular O-2 consumption and down-regulate HIF-1 alpha expression, which successfully rescues cancer cells from becoming hypoxic and relieves the intrinsic hypoxia burden of tumors in vivo, thereby sparing sufficient endogenous O-2 for the PDT process. Photosensitization mechanism studies demonstrate that SORgenTAM has an ideal intersystem crossing rate and triplet excited state lifetime for generating O-2(center dot-) through type-I photochemistry, and the generated O-2(center dot-) can further trigger a biocascade to reduce the PDT's demand for O-2 in an O-2-recycble manner. Furthermore, SORgenTAM also serves to activate the AMPK metabolism signaling pathway to inhibit cell repair and promote cell death. Consequently, using this two-step O-2-economical strategy, under relatively low light dose irradiation, excellent therapeutic responses toward hypoxic tumors are achieved. This study offers a conceptual while practical paradigm for overcoming the pitfalls of phototherapeutics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | TUMOR OXYGENATION | - |
dc.subject | HIGHLY EFFICIENT | - |
dc.subject | CANCER-CELLS | - |
dc.subject | THERAPY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | SUPEROXIDE | - |
dc.subject | METABOLISM | - |
dc.subject | CONVERSION | - |
dc.subject | TAMOXIFEN | - |
dc.title | Unimolecular Photodynamic O-2-Economizer To Overcome Hypoxia Resistance in Phototherapeutics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/jacs.0c00734 | - |
dc.identifier.scopusid | 2-s2.0-85081658833 | - |
dc.identifier.wosid | 000526392600050 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.142, no.11, pp.5380 - 5388 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 142 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5380 | - |
dc.citation.endPage | 5388 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | TUMOR OXYGENATION | - |
dc.subject.keywordPlus | HIGHLY EFFICIENT | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | TAMOXIFEN | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.