Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Global metabolomics analysis of serum from humans at risk of thrombotic stroke

Authors
Khan, AdnanShin, Mal-SoonJee, Sun HaPark, Youngja H.
Issue Date
7-3월-2020
Publisher
ROYAL SOC CHEMISTRY
Keywords
thrombotic stroke
Citation
ANALYST, v.145, no.5, pp.1695 - 1705
Indexed
SCIE
SCOPUS
Journal Title
ANALYST
Volume
145
Number
5
Start Page
1695
End Page
1705
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/57311
DOI
10.1039/c9an02032b
ISSN
0003-2654
Abstract
We aimed to determine the serum concentrations of altered compounds to understand the changes in metabolism and pathophysiology that occur prior to thrombotic stroke. In this prospective cohort study, high-resolution metabolomics (HRM) was employed to analyze serum samples obtained from patients at risk of stroke (n = 99) and non-risk controls (n = 301). Partial least-squares discriminant analysis (PLS-DA), along with univariate analysis using a false discovery rate (FDR) of q = 0.05 were employed to identify the discriminant metabolic profiles and to determine significantly different metabolites between healthy control and stroke risk groups. PLS-DA satisfactorily separated the stroke risk sera from control sera. Additionally, these discriminant metabolic profiles were not related to hypertension, smoking, diabetes mellitus, or insulin sensitivity. A group of 35 metabolites, most of them amino acids, that were capable of discriminating stroke risk sera from controls were identified using untargeted metabolomics. Further, the targeted metabolomics approach confirmed that the quantified concentrations of l-tryptophan, 3-methoxytyramine, methionine, homocysteinesulfinic acid, cysteine, isoleucine, carnitine, arginine, linoleic acid, and sphingosine were specifically elevated in the sera of patients who were later diagnosed with stroke. Our untargeted and targeted metabolomics approaches support investigating these compounds as novel biomarkers for early and non-invasive detection of thrombotic stroke.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Culture and Sports > Division of Global Sport Studies > 1. Journal Articles
College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE