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Laminarin-Derived from Brown Algae Suppresses the Growth of Ovarian Cancer Cells via Mitochondrial Dysfunction and ER Stress

Authors
Bae, HyocheolSong, GwonhwaLee, Jin-YoungHong, TaeyeonChang, Moon-JeongLim, Whasun
Issue Date
3월-2020
Publisher
MDPI
Keywords
laminarin; ovarian cancer; mitochondria; ER stress; cell death
Citation
MARINE DRUGS, v.18, no.3
Indexed
SCIE
SCOPUS
Journal Title
MARINE DRUGS
Volume
18
Number
3
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/57381
DOI
10.3390/md18030152
ISSN
1660-3397
Abstract
Ovarian cancer (OC) is difficult to diagnose at an early stage and leads to the high mortality rate reported in the United States. Standard treatment for OC includes maximal cytoreductive surgery followed by platinum-based chemotherapy. However, relapse due to chemoresistance is common in advanced OC patients. Therefore, it is necessary to develop new anticancer drugs to suppress OC progression. Recently, the anticancer effects of laminarin, a beta-1,3-glucan derived from brown algae, have been reported in hepatocellular carcinoma, colon cancer, leukemia, and melanoma. However, its effects in OC are not reported. We confirmed that laminarin decreases cell growth and cell cycle progression of OC cells through the regulation of intracellular signaling. Moreover, laminarin induced cell death through DNA fragmentation, reactive oxygen species generation, induction of apoptotic signals and endoplasmic reticulum (ER) stress, regulation of calcium levels, and alteration of the ER-mitochondria axis. Laminarin was not cytotoxic in a zebrafish model, while in a zebrafish xenograft model, it inhibited OC cell growth. These results suggest that laminarin may be successfully used as a novel OC suppressor.
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