Differential circulating and visceral fat microRNA expression of non-obese and obese subjects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Ahn, Jiyun | - |
dc.contributor.author | Choi, Yong Min | - |
dc.contributor.author | Son, Hyo Jung | - |
dc.contributor.author | Choi, Won Hee | - |
dc.contributor.author | Cho, Hyun Joo | - |
dc.contributor.author | Yu, Ji Hee | - |
dc.contributor.author | Seo, Ji A. | - |
dc.contributor.author | Jang, Young Jin | - |
dc.contributor.author | Jung, Chang Hwa | - |
dc.contributor.author | Ha, Tae Youl | - |
dc.date.accessioned | 2021-08-31T08:37:17Z | - |
dc.date.available | 2021-08-31T08:37:17Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57396 | - |
dc.description.abstract | Background & aims: Altered microRNA (miRNA) expression is associated with the pathophysiology of obesity; however, little is known about the miRNAs commonly dysregulated in the blood and visceral fat tissue of obese patients. This study compared the circulating and visceral fat miRNA expression in subjects with and without obesity. Methods: For the circulating miRNA study, 20 healthy control and 30 obese subjects were recruited. For the tissue miRNA expression study, omental fat tissue was collected in ten female subjects each in the control and obese groups. MiRNA expression was measured by TaqMan low-density arrays. Metabolic risk factors were measured. Target genes for selected miRNAs were analyzed using informatics tools and a functional network map was constructed. Results: 11 miRNAs were down-regulated (miR-133a, -139-5p, -15b, -26a, -301, -30b, -30c, -374, -451, -570, and -636), and one was up-regulated (miR-155) in both depots in obese subjects. These miRNAs had significant associations with BMI, waist circumference, and fat mass. Among them, miR-15b, miR-26a, miR-301, miR-30b, and miR-30c had more predicted obesity-related target genes than other miRNAs. In particular, miR-15b had numerous target genes associated with adipogenesis, mammalian target of rapamycin (mTOR) signaling, diabetes and insulin resistance, and mitochondrial function. Conclusions: It is suggested that the miRNA alteration in the serum and visceral fat has pathophysiological implications for obesity. Our study identified dysregulated miRNAs that may be novel therapeutic targets to combat obesity. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | REPRESSION | - |
dc.subject | DIAGNOSIS | - |
dc.subject | GLUCOSE | - |
dc.subject | MUSCLE | - |
dc.subject | SERUM | - |
dc.subject | TWINS | - |
dc.title | Differential circulating and visceral fat microRNA expression of non-obese and obese subjects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.contributor.affiliatedAuthor | Yu, Ji Hee | - |
dc.contributor.affiliatedAuthor | Seo, Ji A. | - |
dc.identifier.doi | 10.1016/j.clnu.2019.03.033 | - |
dc.identifier.scopusid | 2-s2.0-85064272631 | - |
dc.identifier.wosid | 000521509800030 | - |
dc.identifier.bibliographicCitation | CLINICAL NUTRITION, v.39, no.3, pp.910 - 916 | - |
dc.relation.isPartOf | CLINICAL NUTRITION | - |
dc.citation.title | CLINICAL NUTRITION | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 910 | - |
dc.citation.endPage | 916 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | TWINS | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Visceral fat | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Circulating gene | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.