Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
- Authors
- Wong, Jason Y. Y.; Zhang, Han; Hsiung, Chao A.; Shiraishi, Kouya; Yu, Kai; Matsuo, Keitaro; Wong, Maria Pik; Hong, Yun-Chul; Wang, Jiucun; Seow, Wei Jie; Wang, Zhaoming; Song, Minsun; Kim, Hee Nam; Chang, I-Shou; Chatterjee, Nilanjan; Hu, Wei; Wu, Chen; Mitsudomi, Tetsuya; Zheng, Wei; Kim, Jin Hee; Seow, Adeline; Caporaso, Neil E.; Shin, Min-Ho; Chung, Lap Ping; An, She-Juan; Wang, Ping; Yang, Yang; Zheng, Hong; Yatabe, Yasushi; Zhang, Xu-Chao; Kim, Young Tae; Cai, Qiuyin; Yin, Zhihua; Kim, Young-Chul; Bassig, Bryan A.; Chang, Jiang; Ho, James Chung N.; Ji, Bu-Tian; Daigo, Yataro; Ito, Hidemi; Momozawa, Yukihide; Ashikawa, Kyota; Kamatani, Yoichiro; Honda, Takayuki; Hosgood, H. Dean; Sakamoto, Hiromi; Kunitoh, Hideo; Tsuta, Koji; Watanabe, Shun-Ichi; Kubo, Michiaki; Miyagi, Yohei; Nakayama, Haruhiko; Matsumoto, Shingo; Tsuboi, Masahiro; Goto, Koichi; Shi, Jianxin; Song, Lei; Hua, Xing; Takahashi, Atsushi; Goto, Akiteru; Minamiya, Yoshihiro; Shimizu, Kimihiro; Tanaka, Kazumi; Wei, Fusheng; Matsuda, Fumihiko; Su, Jian; Kim, Yeul Hong; Oh, In-Jae; Song, Fengju; Su, Wu-Chou; Chen, Yu-Min; Chang, Gee-Chen; Chen, Kuan-Yu; Huang, Ming-Shyan; Chien, Li-Hsin; Xiang, Yong-Bing; Park, Jae Yong; Kweon, Sun-Seog; Chen, Chien-Jen; Lee, Kyoung-Mu; Blechter, Batel; Li, Haixin; Gao, Yu-Tang; Qian, Biyun; Lu, Daru; Liu, Jianjun; Jeon, Hyo-Sung; Hsiao, Chin-Fu; Sung, Jae Sook; Tsai, Ying-Huang; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Wang, Wen-Chang; Chung, Charles C.; Burdett, Laurie; Yeager, Meredith; Hutchinson, Amy; Berndt, Sonja, I; Wu, Wei; Pang, Herbert; Li, Yuqing; Choi, Jin Eun; Park, Kyong Hwa; Sung, Sook Whan; Liu, Li; Kang, C. H.; Zhu, Meng; Chen, Chung-Hsing; Yang, Tsung-Ying; Xu, Jun; Guan, Peng; Tan, Wen; Wang, Chih-Liang; Hsin, Michael; Sit, Ko-Yung; Chen, Ying; Choi, Yi Young; Hung, Jen-Yu; Kim, Jun Suk; Il Yoon, Ho; Lin, Chien-Chung; Park, In Kyu; Xu, Ping; Wang, Yuzhuo; He, Qincheng; Perng, Reury-Perng; Chen, Chih-Yi; Vermeulen, Roel; Wu, Junjie; Lim, Wei-Yen; Chen, Kun-Chieh; Li, Yao-Jen; Li, Jihua; Chen, Hongyan; Yu, Chong-Jen; Jin, Li; Chen, Tzu-Yu; Jiang, Shih-Sheng; Liu, Jie; Yamaji, Taiki; Hicks, Belynda; Wyatt, Kathleen; Li, Shengchao A.; Dai, Juncheng; Ma, Hongxia; Jin, Guangfu; Song, Bao; Wang, Zhehai; Cheng, Sensen; Li, Xuelian; Ren, Yangwu; Cui, Ping; Iwasaki, Motoki; Shimazu, Taichi; Tsugane, Shoichiro; Zhu, Junjie; Yang, Kaiyun; Jiang, Gening; Fei, Ke; Wu, Guoping; Lin, Hsien-Chin; Chen, Hui-Ling; Fang, Yao-Huei; Tsai, Fang-Yu; Hsieh, Wan-Shan; Yu, Jinming; Stevens, Victoria L.; Laird-Offringa, Ite A.; Marconett, Crystal N.; Rieswijk, Linda; Chao, Ann; Yang, Pan-Chyr; Shu, Xiao-Ou; Wu, Tangchun; Wu, Y. L.; Lin, Dongxin; Chen, Kexin; Zhou, Baosen; Huang, Yun-Chao; Kohno, Takashi; Shen, Hongbing; Chanock, Stephen J.; Rothman, Nathaniel; Lan, Qing
- Issue Date
- 3월-2020
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Tuberculosis; Lung cancer; Lung adenocarcinoma; Mendelian randomization; Pathway analysis
- Citation
- GENOMICS, v.112, no.2, pp.1223 - 1232
- Indexed
- SCIE
SCOPUS
- Journal Title
- GENOMICS
- Volume
- 112
- Number
- 2
- Start Page
- 1223
- End Page
- 1232
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/57520
- DOI
- 10.1016/j.ygeno.2019.07.008
- ISSN
- 0888-7543
- Abstract
- We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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