High-resolution metabolomics study revealing L-homocysteine sulfinic acid, cysteic acid, and carnitine as novel biomarkers for high acute myocardial infarction risk
DC Field | Value | Language |
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dc.contributor.author | Khan, Adnan | - |
dc.contributor.author | Choi, Yoonjeong | - |
dc.contributor.author | Back, Joung Hwan | - |
dc.contributor.author | Lee, Sunmi | - |
dc.contributor.author | Jee, Sun Ha | - |
dc.contributor.author | Park, Youngja H. | - |
dc.date.accessioned | 2021-08-31T08:55:30Z | - |
dc.date.available | 2021-08-31T08:55:30Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57523 | - |
dc.description.abstract | Background: Identifying changes in serum metabolites before the occurrence of acute myocardial infarction (AMI) is an important approach for finding novel biomarkers of AMI. Methods: In this prospective cohort study, scrum samples obtained from patients at risk of AMI (n = 112) and non-risk controls (n = 89) were tested using high-resolution metabolomics (HRM). Partial least-squares discriminant analysis (PLS-DA), along with univariate analysis using a false discovery rate (FDR) of q = 0.05 were performed to discriminate metabolic profiles and to determine significantly different metabolites between healthy control and AMI risk groups. Results: PLS-DA significantly separated the AMI risk sera from control sera. The metabolites associated with amino acid biosynthesis, 2-oxocarboxylic add, ttyptophan, and amino sugar and nucleotide sugar metabolism pathways were mainly elevated in patients at risk of AMI. Further validation and quantification by MS/MS showed that tryptophan, camitine, L-homocysteine sulfinic acid (L-HCSA), and cysteic acid (CA) were upregulated, while L-cysteine and L-cysteine sulfinic acid (L-CSA) were downregulated, specifically among AMI risk sera. Additionally, these discriminant metabolic profiles were not related to hypertension, smoking or alcoholism. Conclusion: In conclusion, detecting upregulated L-HCSA and CA along with camitine among patients at risk for AMI could serve as promising non-invasive biomarkers for early AMI detection. (C) 2019 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | AMINO-ACIDS | - |
dc.subject | PLASMA HOMOCYSTEINE | - |
dc.subject | DIAGNOSTIC MARKER | - |
dc.subject | TROPONIN-I | - |
dc.subject | GLUTAMATE | - |
dc.subject | SMOKING | - |
dc.subject | SERUM | - |
dc.subject | ASSOCIATION | - |
dc.title | High-resolution metabolomics study revealing L-homocysteine sulfinic acid, cysteic acid, and carnitine as novel biomarkers for high acute myocardial infarction risk | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Youngja H. | - |
dc.identifier.doi | 10.1016/j.metabol.2019.154051 | - |
dc.identifier.scopusid | 2-s2.0-85077657134 | - |
dc.identifier.wosid | 000518471400004 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.104 | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.title | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.volume | 104 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | PLASMA HOMOCYSTEINE | - |
dc.subject.keywordPlus | DIAGNOSTIC MARKER | - |
dc.subject.keywordPlus | TROPONIN-I | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordPlus | SMOKING | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | Mass spectrometry | - |
dc.subject.keywordAuthor | Metabolomics | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Riomarker | - |
dc.subject.keywordAuthor | Homocysteine | - |
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